HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Albertus T. J. Wierenga; Alan Cunningham; Ayşegül Erdem; Nuria Vilaplana Lopera; Annet Z. Brouwers-Vos; Maurien Pruis; André B. Mulder; Ulrich L. Günther; Joost H. A. Martens; Edo Vellenga; Jan Jacob Schuringa

doi:10.1186/s40170-019-0206-y

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Albertus T. J. Wierenga, Alan Cunningham, Ayşegül Erdem, Nuria Vilaplana Lopera, Annet Z. Brouwers-Vos, Maurien Pruis, André B. Mulder, Ulrich L. Günther, Joost H. A. Martens, Edo Vellenga, Jan Jacob Schuringa

Institute of Chemistry and Metabolomics

Abstract

Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

Original language	English
Article number	11
Journal	Cancer & Metabolism
Volume	7
Issue number	1
ISSN	2049-3002
DOIs	https://doi.org/10.1186/s40170-019-0206-y
Publication status	Published - 27.12.2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

Access to Document

10.1186/s40170-019-0206-y

Cite this

Wierenga, A. T. J., Cunningham, A., Erdem, A., Lopera, N. V., Brouwers-Vos, A. Z., Pruis, M., Mulder, A. B., Günther, U. L., Martens, J. H. A., Vellenga, E., & Schuringa, J. J. (2019). HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells. Cancer & Metabolism, 7(1), Article 11. https://doi.org/10.1186/s40170-019-0206-y

@article{9f70c194e4bf492cb9607dd61ab8c325,

title = "HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells",

abstract = "Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.",

author = "Wierenga, \{Albertus T. J.\} and Alan Cunningham and Ay{\c s}eg{\"u}l Erdem and Lopera, \{Nuria Vilaplana\} and Brouwers-Vos, \{Annet Z.\} and Maurien Pruis and Mulder, \{Andr{\'e} B.\} and G{\"u}nther, \{Ulrich L.\} and Martens, \{Joost H. A.\} and Edo Vellenga and Schuringa, \{Jan Jacob\}",

year = "2019",

month = dec,

day = "27",

doi = "10.1186/s40170-019-0206-y",

language = "English",

volume = "7",

journal = "Cancer \& Metabolism",

issn = "2049-3002",

number = "1",

}

Wierenga, ATJ, Cunningham, A, Erdem, A, Lopera, NV, Brouwers-Vos, AZ, Pruis, M, Mulder, AB, Günther, UL, Martens, JHA, Vellenga, E & Schuringa, JJ 2019, 'HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells', Cancer & Metabolism, vol. 7, no. 1, 11. https://doi.org/10.1186/s40170-019-0206-y

TY - JOUR

T1 - HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

AU - Wierenga, Albertus T. J.

AU - Cunningham, Alan

AU - Erdem, Ayşegül

AU - Lopera, Nuria Vilaplana

AU - Brouwers-Vos, Annet Z.

AU - Pruis, Maurien

AU - Mulder, André B.

AU - Günther, Ulrich L.

AU - Martens, Joost H. A.

AU - Vellenga, Edo

AU - Schuringa, Jan Jacob

PY - 2019/12/27

Y1 - 2019/12/27

N2 - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

AB - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.

UR - https://www.researchgate.net/publication/338199401_HIF12-exerted_control_over_glycolytic_gene_expression_is_not_functionally_relevant_for_glycolysis_in_human_leukemic_stemprogenitor_cells

U2 - 10.1186/s40170-019-0206-y

DO - 10.1186/s40170-019-0206-y

M3 - Journal articles

SN - 2049-3002

VL - 7

JO - Cancer & Metabolism

JF - Cancer & Metabolism

IS - 1

M1 - 11

ER -

HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells

Abstract

UN SDGs

Research Areas and Centers

Access to Document

Other files and links

Fingerprint

Cite this