TY - JOUR
T1 - HIF1/2-exerted control over glycolytic gene expression is not functionally relevant for glycolysis in human leukemic stem/progenitor cells
AU - Wierenga, Albertus T. J.
AU - Cunningham, Alan
AU - Erdem, Ayşegül
AU - Lopera, Nuria Vilaplana
AU - Brouwers-Vos, Annet Z.
AU - Pruis, Maurien
AU - Mulder, André B.
AU - Günther, Ulrich L.
AU - Martens, Joost H. A.
AU - Vellenga, Edo
AU - Schuringa, Jan Jacob
PY - 2019/12/27
Y1 - 2019/12/27
N2 - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.
AB - Hypoxia-inducible factors (HIF)1 and 2 are transcription factors that regulate the homeostatic response to low oxygen conditions. Since data related to the importance of HIF1 and 2 in hematopoietic stem and progenitors is conflicting, we investigated the chromatin binding profiles of HIF1 and HIF2 and linked that to transcriptional networks and the cellular metabolic state.
UR - https://www.researchgate.net/publication/338199401_HIF12-exerted_control_over_glycolytic_gene_expression_is_not_functionally_relevant_for_glycolysis_in_human_leukemic_stemprogenitor_cells
U2 - 10.1186/s40170-019-0206-y
DO - 10.1186/s40170-019-0206-y
M3 - Journal articles
SN - 2049-3002
VL - 7
JO - Cancer & Metabolism
JF - Cancer & Metabolism
IS - 1
M1 - 11
ER -
