Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues

Ksenia Pumpor; Christoph Böttcher; Susanna Fehn; Klaus Burger

doi:10.3987/com-03-s34

Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues

Ksenia Pumpor, Christoph Böttcher, Susanna Fehn, Klaus Burger^*

^*Corresponding author for this work

Institute of Biochemistry

University of Leipzig

9 Citations (Scopus)

Abstract

Hexafluoroacetone-protected glutamic acid on treatment with thionyl chloride is transformed into a carboxy-activated pyroglutamic acid derivative. Likewise, the reaction sequence can be applied to aminoadipic acid and homologues.

Original language	English
Journal	Heterocycles
Volume	61
Pages (from-to)	259-269
Number of pages	11
ISSN	0385-5414
DOIs	https://doi.org/10.3987/com-03-s34
Publication status	Published - 31.12.2003

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Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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10.3987/com-03-s34

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title = "Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues",

abstract = "Hexafluoroacetone-protected glutamic acid on treatment with thionyl chloride is transformed into a carboxy-activated pyroglutamic acid derivative. Likewise, the reaction sequence can be applied to aminoadipic acid and homologues.",

author = "Ksenia Pumpor and Christoph B{\"o}ttcher and Susanna Fehn and Klaus Burger",

year = "2003",

month = dec,

day = "31",

doi = "10.3987/com-03-s34",

language = "English",

volume = "61",

pages = "259--269",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues

AU - Pumpor, Ksenia

AU - Böttcher, Christoph

AU - Fehn, Susanna

AU - Burger, Klaus

PY - 2003/12/31

Y1 - 2003/12/31

N2 - Hexafluoroacetone-protected glutamic acid on treatment with thionyl chloride is transformed into a carboxy-activated pyroglutamic acid derivative. Likewise, the reaction sequence can be applied to aminoadipic acid and homologues.

AB - Hexafluoroacetone-protected glutamic acid on treatment with thionyl chloride is transformed into a carboxy-activated pyroglutamic acid derivative. Likewise, the reaction sequence can be applied to aminoadipic acid and homologues.

UR - https://www.scopus.com/pages/publications/0347022244

U2 - 10.3987/com-03-s34

DO - 10.3987/com-03-s34

M3 - Journal articles

AN - SCOPUS:0347022244

SN - 0385-5414

VL - 61

SP - 259

EP - 269

JO - Heterocycles

JF - Heterocycles

ER -

Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues

Abstract

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