Hexafluoroacetone as protecting and activating reagent: An efficient strategy for activation of pyroglutamic acid and homologues

Ksenia Pumpor, Christoph Böttcher, Susanna Fehn, Klaus Burger*

*Corresponding author for this work
6 Citations (Scopus)

Abstract

Hexafluoroacetone-protected glutamic acid on treatment with thionyl chloride is transformed into a carboxy-activated pyroglutamic acid derivative. Likewise, the reaction sequence can be applied to aminoadipic acid and homologues.

Original languageEnglish
JournalHeterocycles
Volume61
Pages (from-to)259-269
Number of pages11
ISSN0385-5414
DOIs
Publication statusPublished - 31.12.2003

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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