Heterogeneity of head and neck squamous cell carcinoma stem cells

Xu Qian; Xiaobo Nie; Barbara Wollenberg; Holger Sudhoff; Andreas M. Kaufmann; Andreas E. Albers

doi:10.1007/978-3-030-14366-4_2

Heterogeneity of head and neck squamous cell carcinoma stem cells

Xu Qian, Xiaobo Nie, Barbara Wollenberg, Holger Sudhoff, Andreas M. Kaufmann, Andreas E. Albers^*

^*Corresponding author for this work

Clinic of Otorhinolaryngology

11 Citations (Scopus)

Abstract

Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

Original language	English
Title of host publication	Advances in Experimental Medicine and Biology
Editors	Alexander Birbrair
Number of pages	18
Place of Publication	Cham
Publisher	Springer New York LLC
Publication date	28.05.2019
Pages	23-40
ISBN (Print)	978-3-030-14365-7
ISBN (Electronic)	978-3-030-14366-4
DOIs	https://doi.org/10.1007/978-3-030-14366-4_2
Publication status	Published - 28.05.2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

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10.1007/978-3-030-14366-4_2

Cite this

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title = "Heterogeneity of head and neck squamous cell carcinoma stem cells",

abstract = "Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.",

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Heterogeneity of head and neck squamous cell carcinoma stem cells. / Qian, Xu; Nie, Xiaobo; Wollenberg, Barbara et al.
Advances in Experimental Medicine and Biology. ed. / Alexander Birbrair. Cham: Springer New York LLC, 2019. p. 23-40 (Advances in Experimental Medicine and Biology; Vol. 1139).

Research output: Chapters in Books/Reports/Conference Proceedings › Chapter › peer-review

TY - CHAP

T1 - Heterogeneity of head and neck squamous cell carcinoma stem cells

AU - Qian, Xu

AU - Nie, Xiaobo

AU - Wollenberg, Barbara

AU - Sudhoff, Holger

AU - Kaufmann, Andreas M.

AU - Albers, Andreas E.

PY - 2019/5/28

Y1 - 2019/5/28

N2 - Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

AB - Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

UR - https://www.scopus.com/pages/publications/85066265848

U2 - 10.1007/978-3-030-14366-4_2

DO - 10.1007/978-3-030-14366-4_2

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C2 - 31134493

AN - SCOPUS:85066265848

SN - 978-3-030-14365-7

T3 - Advances in Experimental Medicine and Biology

SP - 23

EP - 40

BT - Advances in Experimental Medicine and Biology

A2 - Birbrair, Alexander

PB - Springer New York LLC

CY - Cham

ER -

Heterogeneity of head and neck squamous cell carcinoma stem cells

Abstract

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Research Areas and Centers

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