Abstract
Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Editors | Alexander Birbrair |
| Number of pages | 18 |
| Place of Publication | Cham |
| Publisher | Springer New York LLC |
| Publication date | 28.05.2019 |
| Pages | 23-40 |
| ISBN (Print) | 978-3-030-14365-7 |
| ISBN (Electronic) | 978-3-030-14366-4 |
| DOIs | |
| Publication status | Published - 28.05.2019 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)
