Heterogeneity of head and neck squamous cell carcinoma stem cells

Xu Qian, Xiaobo Nie, Barbara Wollenberg, Holger Sudhoff, Andreas M. Kaufmann, Andreas E. Albers*

*Corresponding author for this work
4 Citations (Scopus)


Current systemic cancer treatment in head and neck squamous cell carcinoma (HNSCC) is moving toward more personalized approaches such as de-escalation protocols human-papilloma-virus dependent HNSCC or application of checkpoint inhibitors. However, these treatments have been challenged by cancer stem cells (CSC), a small population within the bulk tumor, which are leading to treatment failure, tumor recurrence, or metastases. This review will give an overview of the characteristics of HNSCC-CSC. Specifically, the mechanisms by which HNSCC-CSC induce tumor initiation, progression, recurrence, or metastasis will be discussed. Although evidence-based treatment options targeting HNSCC-CSC specifically are still being sought for, they warrant a promise for additional and sustainable treatment options where for HNSCC patients where others have failed.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
EditorsAlexander Birbrair
Number of pages18
Place of PublicationCham
PublisherSpringer New York LLC
Publication date28.05.2019
ISBN (Print)978-3-030-14365-7
ISBN (Electronic)978-3-030-14366-4
Publication statusPublished - 28.05.2019

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)


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