Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications

Antonia M. Joussen; Bernd Kirchhof; Norbert Schrage; Christina Ocklenburg; Ralf Dieter Hilgers; Bernd Kirchhof; Antonia M. Joussen; Ralf Dieter Hilgers; Christina Ocklenburg; Bernd Kirchhof; Ralf Dieter Hilgers; Klaus Dieter Lemmen; Antonia M. Joussen; Ralf Dieter Hilgers; Christina Ocklenburg; Ulrich Bartz-Schmidt; Nikolaos Bechrakis; Susanne Binder; Norbert Bornfeld; Arnd Bunse; Jan Olof Carlsson; Sven Crafoord; Claudia Dahlke; Stefan Dithmar; Katrin Engelmann; Nicole Eter; Michael H. Foerster; Salvatore Grisanti; Carl Groenewald; Heinrich Heimann; Hans Hoerauf; Frank G. Holz; Bernd Kirchhof; Xiaoxin Li; Albrecht Lommatzsch; Jerzy Mackiewicz; Angelina Meireles; Maya Müller; Koen van Overdam; Ian Pearce; Ed Peperkamp; Stanislao Rizzo; Johann Roider; György Salacz; Norbert Schrage; Steven Schwartz; Guy Shanks; Ulrike Stolba; Peter Szurman; Marc Veckeneer; Peter Walter; Burkhard Wiechens; David Wong; Katja Höhne; Dominique Ottenberg; Erik Domeier; Daniel Handzel; Carsten Klatt; Beate Prinz; Helene Llacer; Sandra Jöres; Christine Kusserow; Efdal Yörük; P. Jungfermann; Isabel Krömer; Julia Wrede; Maria Herrmann; G. Varapi; Liz Garnett; Gillian Hebbar; Andreas Lipski; Markus Rindsfüser; Laila Eriksson; Claudia Belting

doi:10.1111/j.1600-0420.2007.00898.x

Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications

Antonia M. Joussen, Bernd Kirchhof, Norbert Schrage, Christina Ocklenburg, Ralf Dieter Hilgers, Bernd Kirchhof, Antonia M. Joussen, Ralf Dieter Hilgers, Christina Ocklenburg, Bernd Kirchhof, Ralf Dieter Hilgers, Klaus Dieter Lemmen, Antonia M. Joussen, Ralf Dieter Hilgers, Christina Ocklenburg, Ulrich Bartz-Schmidt, Nikolaos Bechrakis, Susanne Binder, Norbert Bornfeld, Arnd BunseJan Olof Carlsson, Sven Crafoord, Claudia Dahlke, Stefan Dithmar, Katrin Engelmann, Nicole Eter, Michael H. Foerster, Salvatore Grisanti, Carl Groenewald, Heinrich Heimann, Hans Hoerauf, Frank G. Holz, Bernd Kirchhof, Xiaoxin Li, Albrecht Lommatzsch, Jerzy Mackiewicz, Angelina Meireles, Maya Müller, Koen van Overdam, Ian Pearce, Ed Peperkamp, Stanislao Rizzo, Johann Roider, György Salacz, Norbert Schrage, Steven Schwartz, Guy Shanks, Ulrike Stolba, Peter Szurman, Marc Veckeneer, Peter Walter, Burkhard Wiechens, David Wong, Katja Höhne, Dominique Ottenberg, Erik Domeier, Daniel Handzel, Carsten Klatt, Beate Prinz, Helene Llacer, Sandra Jöres, Christine Kusserow, Efdal Yörük, P. Jungfermann, Isabel Krömer, Julia Wrede, Maria Herrmann, G. Varapi, Liz Garnett, Gillian Hebbar, Andreas Lipski, Markus Rindsfüser, Laila Eriksson, Claudia Belting

Clinic of Ophtalmology

39 Citations (Scopus)

Abstract

Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron® as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR.

Original language	English
Journal	Acta Ophthalmologica Scandinavica
Volume	85
Issue number	6
Pages (from-to)	623-630
Number of pages	8
ISSN	1395-3907
DOIs	https://doi.org/10.1111/j.1600-0420.2007.00898.x
Publication status	Published - 09.2007

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1600-0420.2007.00898.x

Cite this

Joussen, A. M., Kirchhof, B., Schrage, N., Ocklenburg, C., Hilgers, R. D., Kirchhof, B., Joussen, A. M., Hilgers, R. D., Ocklenburg, C., Kirchhof, B., Hilgers, R. D., Lemmen, K. D., Joussen, A. M., Hilgers, R. D., Ocklenburg, C., Bartz-Schmidt, U., Bechrakis, N., Binder, S., Bornfeld, N., ... Belting, C. (2007). Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications. Acta Ophthalmologica Scandinavica, 85(6), 623-630. https://doi.org/10.1111/j.1600-0420.2007.00898.x

@article{1cd86d7a1f6d4882a7ea22988df9259b,

title = "Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications",

abstract = "Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron{\textregistered} as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR.",

author = "Joussen, {Antonia M.} and Bernd Kirchhof and Norbert Schrage and Christina Ocklenburg and Hilgers, {Ralf Dieter} and Bernd Kirchhof and Joussen, {Antonia M.} and Hilgers, {Ralf Dieter} and Christina Ocklenburg and Bernd Kirchhof and Hilgers, {Ralf Dieter} and Lemmen, {Klaus Dieter} and Joussen, {Antonia M.} and Hilgers, {Ralf Dieter} and Christina Ocklenburg and Ulrich Bartz-Schmidt and Nikolaos Bechrakis and Susanne Binder and Norbert Bornfeld and Arnd Bunse and Carlsson, {Jan Olof} and Sven Crafoord and Claudia Dahlke and Stefan Dithmar and Katrin Engelmann and Nicole Eter and Foerster, {Michael H.} and Salvatore Grisanti and Carl Groenewald and Heinrich Heimann and Hans Hoerauf and Holz, {Frank G.} and Bernd Kirchhof and Xiaoxin Li and Albrecht Lommatzsch and Jerzy Mackiewicz and Angelina Meireles and Maya M{\"u}ller and {van Overdam}, Koen and Ian Pearce and Ed Peperkamp and Stanislao Rizzo and Johann Roider and Gy{\"o}rgy Salacz and Norbert Schrage and Steven Schwartz and Guy Shanks and Ulrike Stolba and Peter Szurman and Marc Veckeneer and Peter Walter and Burkhard Wiechens and David Wong and Katja H{\"o}hne and Dominique Ottenberg and Erik Domeier and Daniel Handzel and Carsten Klatt and Beate Prinz and Helene Llacer and Sandra J{\"o}res and Christine Kusserow and Efdal Y{\"o}r{\"u}k and P. Jungfermann and Isabel Kr{\"o}mer and Julia Wrede and Maria Herrmann and G. Varapi and Liz Garnett and Gillian Hebbar and Andreas Lipski and Markus Rindsf{\"u}ser and Laila Eriksson and Claudia Belting",

year = "2007",

month = sep,

doi = "10.1111/j.1600-0420.2007.00898.x",

language = "English",

volume = "85",

pages = "623--630",

journal = "Acta Ophthalmologica Scandinavica",

issn = "1395-3907",

number = "6",

}

Joussen, AM, Kirchhof, B, Schrage, N, Ocklenburg, C, Hilgers, RD, Kirchhof, B, Joussen, AM, Hilgers, RD, Ocklenburg, C, Kirchhof, B, Hilgers, RD, Lemmen, KD, Joussen, AM, Hilgers, RD, Ocklenburg, C, Bartz-Schmidt, U, Bechrakis, N, Binder, S, Bornfeld, N, Bunse, A, Carlsson, JO, Crafoord, S, Dahlke, C, Dithmar, S, Engelmann, K, Eter, N, Foerster, MH, Grisanti, S, Groenewald, C, Heimann, H, Hoerauf, H, Holz, FG, Kirchhof, B, Li, X, Lommatzsch, A, Mackiewicz, J, Meireles, A, Müller, M, van Overdam, K, Pearce, I, Peperkamp, E, Rizzo, S, Roider, J, Salacz, G, Schrage, N, Schwartz, S, Shanks, G, Stolba, U, Szurman, P, Veckeneer, M, Walter, P, Wiechens, B, Wong, D, Höhne, K, Ottenberg, D, Domeier, E, Handzel, D, Klatt, C, Prinz, B, Llacer, H, Jöres, S, Kusserow, C, Yörük, E, Jungfermann, P, Krömer, I, Wrede, J, Herrmann, M, Varapi, G, Garnett, L, Hebbar, G, Lipski, A, Rindsfüser, M, Eriksson, L & Belting, C 2007, 'Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications', Acta Ophthalmologica Scandinavica, vol. 85, no. 6, pp. 623-630. https://doi.org/10.1111/j.1600-0420.2007.00898.x

TY - JOUR

T1 - Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications

AU - Joussen, Antonia M.

AU - Kirchhof, Bernd

AU - Schrage, Norbert

AU - Ocklenburg, Christina

AU - Hilgers, Ralf Dieter

AU - Kirchhof, Bernd

AU - Joussen, Antonia M.

AU - Hilgers, Ralf Dieter

AU - Ocklenburg, Christina

AU - Kirchhof, Bernd

AU - Hilgers, Ralf Dieter

AU - Lemmen, Klaus Dieter

AU - Joussen, Antonia M.

AU - Hilgers, Ralf Dieter

AU - Ocklenburg, Christina

AU - Bartz-Schmidt, Ulrich

AU - Bechrakis, Nikolaos

AU - Binder, Susanne

AU - Bornfeld, Norbert

AU - Bunse, Arnd

AU - Carlsson, Jan Olof

AU - Crafoord, Sven

AU - Dahlke, Claudia

AU - Dithmar, Stefan

AU - Engelmann, Katrin

AU - Eter, Nicole

AU - Foerster, Michael H.

AU - Grisanti, Salvatore

AU - Groenewald, Carl

AU - Heimann, Heinrich

AU - Hoerauf, Hans

AU - Holz, Frank G.

AU - Kirchhof, Bernd

AU - Li, Xiaoxin

AU - Lommatzsch, Albrecht

AU - Mackiewicz, Jerzy

AU - Meireles, Angelina

AU - Müller, Maya

AU - van Overdam, Koen

AU - Pearce, Ian

AU - Peperkamp, Ed

AU - Rizzo, Stanislao

AU - Roider, Johann

AU - Salacz, György

AU - Schrage, Norbert

AU - Schwartz, Steven

AU - Shanks, Guy

AU - Stolba, Ulrike

AU - Szurman, Peter

AU - Veckeneer, Marc

AU - Walter, Peter

AU - Wiechens, Burkhard

AU - Wong, David

AU - Höhne, Katja

AU - Ottenberg, Dominique

AU - Domeier, Erik

AU - Handzel, Daniel

AU - Klatt, Carsten

AU - Prinz, Beate

AU - Llacer, Helene

AU - Jöres, Sandra

AU - Kusserow, Christine

AU - Yörük, Efdal

AU - Jungfermann, P.

AU - Krömer, Isabel

AU - Wrede, Julia

AU - Herrmann, Maria

AU - Varapi, G.

AU - Garnett, Liz

AU - Hebbar, Gillian

AU - Lipski, Andreas

AU - Rindsfüser, Markus

AU - Eriksson, Laila

AU - Belting, Claudia

PY - 2007/9

Y1 - 2007/9

N2 - Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron® as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR.

AB - Purpose: Proliferative vitreoretinopathy (PVR) is the most important reason for blindness following retinal detachment. Presently, vitreous tamponades such as gas or silicone oil cannot contact the lower part of the retina. A heavier-than-water tamponade displaces the inflammatory and PVR-stimulating environment from the inferior area of the retina. The Heavy Silicone Oil versus Standard Silicone Oil Study (HSO Study) is designed to answer the question of whether a heavier-than-water tamponade improves the prognosis of eyes with PVR of the lower retina. Methods: The HSO Study is a multicentre, randomized, prospective controlled clinical trial comparing two endotamponades within a two-arm parallel group design. Patients with inferiorly and posteriorly located PVR are randomized to either heavy silicone oil or standard silicone oil as a tamponading agent. Three hundred and fifty consecutive patients are recruited per group. After intraoperative re-attachment, patients are randomized to either standard silicone oil (1000 cSt or 5000 cSt) or Densiron® as a tamponading agent. The main endpoint criteria are complete retinal attachment at 12 months and change of visual acuity (VA) 12 months postoperatively compared with the preoperative VA. Secondary endpoints include complete retinal attachment before endotamponade removal, quality of life analysis and the number of retina affecting re-operation within 1 year of follow-up. Results: The design and early recruitment phase of the study are described. Conclusions: The results of this study will uncover whether or not heavy silicone oil improves the prognosis of eyes with PVR.

UR - http://www.scopus.com/inward/record.url?scp=34548250980&partnerID=8YFLogxK

U2 - 10.1111/j.1600-0420.2007.00898.x

DO - 10.1111/j.1600-0420.2007.00898.x

M3 - Journal articles

C2 - 17408389

AN - SCOPUS:34548250980

SN - 1395-3907

VL - 85

SP - 623

EP - 630

JO - Acta Ophthalmologica Scandinavica

JF - Acta Ophthalmologica Scandinavica

IS - 6

ER -

Heavy silicone oil versus standard silicone oil as vitreous tamponade in inferior PVR (HSO Study): Design issues and implications

Abstract

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UN SDGs

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