HD phenocopies - Possible role of saitohin gene

N. Janković, M. Kecmanović, R. Dimitrijević, M. Keckarević Marković, V. Dobričić, D. Keckarević, D. Savić-Pavićević, S. Romac*

*Corresponding author for this work
6 Citations (Scopus)


Saitohin (STH) is located in the intron of the human gene for microtubule-associated protein tau. Q7R polymorphism has been identified in the STH gene. Some neurodegenerative disorders were found to be associated with the presence of certain STH allele. This study genotyped 37 subjects with diagnosis of Huntington's disease, but lacking mutations in HD, PRNP, JPH-3, and FTL genes for STH polymorphism. It was determined that Q allele of STH gene was over-represented in a tested group of patients (P > Pt). Over-representation of Q allele in a group of patients might be considered as genetic risk factor for HD like diseases.

Original languageEnglish
JournalInternational Journal of Neuroscience
Issue number3
Pages (from-to)391-397
Number of pages7
Publication statusPublished - 03.2008


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