Projects per year
Abstract
HAX1 was originally described as HS1-associated protein with a suggested function in receptor-mediated apoptotic and proliferative responses of lymphoid cells. Recent publications refer to a complex and multifunctional role of this protein. To investigate the in vivo function of HAX1 (HS1-associated protein X1) in B cells, we generated a Hax1-deficient mouse strain. Targeted deletion of Hax1 resulted in premature death around the age of 12 wk accompanied by a severe reduction of lymphocytes in spleen, thymus and bone marrow. In the bone marrow, all B-cell populations were lost comparably. In the spleen, B220 + cells were reduced by almost 70%. However, as investigated by adoptive transfer experiments, this impairment is not exclusively B-cell intrinsic and we hypothesize that a HAX1-deficient environment cannot sufficiently provide the essential factors for proper lymphocyte development, trafficking and survival. Hax1 -/- B cells show a significantly reduced expression of CXCR4, which might have an influence on the observed defects in B-cell development.
Original language | English |
---|---|
Journal | European Journal of Immunology |
Volume | 40 |
Issue number | 11 |
Pages (from-to) | 3161-3172 |
Number of pages | 12 |
ISSN | 0014-2980 |
DOIs | |
Publication status | Published - 01.12.2010 |
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
Fingerprint
Dive into the research topics of 'HAX1 deficiency: Impact on lymphopoiesis and B-cell development'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Investigation of the role of the chemokine receptors CCR2 and CXCR3 in B-cell and plasma cell homing and differentiation
Manz, R. (Principal Investigator (PI))
01.01.07 → 31.12.11
Project: DFG Projects › DFG Individual Projects