Hashimoto encephalopathy - Is it underdiagnosed in pediatric patients?

B. V. Maydell, M. Kopp, G. V. Komorowski, A. Joe, F. D. Juengling, R. Korinthenberg*

*Corresponding author for this work
40 Citations (Scopus)


Hashimoto encephalopathy (HE) is associated with Hashimoto thyroiditis. Clinically it presents with variable symptoms like seizures, neuropsychiatric changes or focal neurological deficits. Autoimmune phenomena are hypothesized for the pathogenesis. HE has mainly been described in the adult population. We present two 14-year-old patients who presented with recurrent seizures and mental decline. SPECT and PET scans showed distinctly pathological changes. Both patients were diagnosed with HE and improved dramatically on steroids. We feel that HE is a rare but important differential diagnosis of encephalopathy also in the pediatric population. As this disease responds well to steroids, we recommend to obtain basic thyroid function tests as well as thyroid antibodies in all cases of unexplained encephalopathy or unexplained status epilepticus.

Original languageEnglish
Issue number2
Pages (from-to)86-89
Number of pages4
Publication statusPublished - 2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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