Habituelle Abortneigung: Evidenzbasierte Diagnostik und Therapie

About 1-3% of all couples suffer recurrent miscarriages during their childbearing years. Due to the increase in maternal age at the first pregnancy, especially in Western Europe, there is a tendency to carry an extensive diagnostic work-up after two miscarriages, although the WHO definition of recurrent miscarriage defines it as three or more consecutive pregnancy losses. Causal clarification should primarily focus on possible risk factors for miscarriages while being cost-effective and leading to promising therapeutic consequences. In view of the large number of studies and therapeutic options, an evidence-based concept for diagnostic and therapeutic guidelines on recurrent miscarriages is essential. New treatment strategies need to be confirmed in large randomized placebo-controlled trials.