Guidelines for Long-Term Follow-Up after Childhood Cancer: Practical Implications for the Daily Work

Judith Gebauer, Katja Baust, Edit Bardi, Desiree Grabow, Alexander Stein, Helena J. Van Der Pal, Gabriele Calaminus, Thorsten Langer*

*Corresponding author for this work
1 Citation (Scopus)


Background: Many childhood cancer survivors develop treatment-associated late effects emerging years or even decades after the end of treatment. Evidence-based guidelines recommend risk-adapted screening, facilitating early diagnosis and management of these sequelae. Long-term follow-up (LTFU) in specialized late effects clinics is devised to implement screening recommendations in the care of childhood cancer survivors. Objectives: To create a practical LTFU tool for the daily practice. Methods: Current guidelines and screening recommendations concerning LTFU in adult survivors of childhood cancer were reviewed and a comprehensive LTFU approach was developed. Results: A risk stratification model assigning patients to three risk groups with different screening recommendations and frequencies is presented based on current LTFU guidelines. Furthermore, a model of LTFU in a clinical multidisciplinary team is proposed. Conclusions: Although late morbidity and mortality in childhood cancer survivors have been attenuated in the last decade by reducing treatment toxicities, a high proportion of long-term survivors already is or will still be affected by treatment-associated chronic health conditions. With the knowledge of late effects and their occurrence as a consequence of specific treatment modalities, practical LTFU recommendations are essential to achieve standardized and structured LTFU care.

Original languageEnglish
JournalOncology Research and Treatment
Issue number3
Pages (from-to)61-68
Number of pages8
Publication statusPublished - 01.03.2020


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