Gray matters! - Mapping the transition to psychosis

Stefan Borgwardt; Philip McGuire; Paolo Fusar-Poli

doi:10.1016/j.schres.2011.08.021

Gray matters! - Mapping the transition to psychosis

Stefan Borgwardt^*, Philip McGuire, Paolo Fusar-Poli

^*Corresponding author for this work

Department of Psychiatry, Psychosomatics and Psychotherapie

43 Citations (Scopus)

Abstract

Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.

Original language	English
Journal	Schizophrenia Research
Volume	133
Issue number	1-3
Pages (from-to)	63-67
Number of pages	5
ISSN	0920-9964
DOIs	https://doi.org/10.1016/j.schres.2011.08.021
Publication status	Published - 12.2011

Funding

This research was supported by a personal grant (SJB) provided by the Swiss National Science Foundation (PBBSB 32323B_119382). The sponsor of the study had no role in study design, collection, analysis, interpretation of data, writing of this report, and in the decision to submit the paper for publication.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 10 Reduced Inequalities

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10.1016/j.schres.2011.08.021

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abstract = "Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.",

author = "Stefan Borgwardt and Philip McGuire and Paolo Fusar-Poli",

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AU - Borgwardt, Stefan

AU - McGuire, Philip

AU - Fusar-Poli, Paolo

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N2 - Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.

AB - Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.

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ER -

Gray matters! - Mapping the transition to psychosis

Abstract

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