Granulomatöse Vaskulitiden und Vaskulitiden mit extravaskulärer Granulomatose

Translated title of the contribution: Granulomatous vasculitides and vasculitides with extravascular granulomatosis

Sabrina Arnold, Sebastian Klapa, Konstanze Holl-Ulrich, Antje Müller, Anja Kerstein-Stähle, Peter Lamprecht*

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Vasculitides are inflammatory diseases of blood vessels caused by autoimmune or infectious processes, which are associated with alterations and destruction of the vascular wall. From a histopathological point of view, granulomatous vasculitides can be distinguished from necrotizing vasculitides with respect to the pattern of inflammation. Granulomatous vasculitides are characterized by intramural, predominantly lymphohistiocytic infiltrates with the formation of giant cells. They include giant cell arteritis (GCA) and Takayasu arteritis (TAK). By contrast, anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) belongs to the group of necrotizing vasculitides. AAV includes granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). In addition to systemic necrotizing small vessel vasculitis, GPA and EGPA are characterized by extravascular granulomatous necrotizing inflammation mainly affecting the upper and/or lower respiratory tract, in EGPA with eosinophilic infiltrates. These granulomatous lesions are part of the autoimmune process and associated with tissue damage.

Translated title of the contributionGranulomatous vasculitides and vasculitides with extravascular granulomatosis
Original languageGerman
JournalZeitschrift fur Rheumatologie
Volume81
Issue number7
Pages (from-to)558-566
Number of pages9
ISSN0340-1855
DOIs
Publication statusPublished - 09.2022

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

DFG Research Classification Scheme

  • 205-18 Rheumatology

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