TY - JOUR
T1 - Goal-directed colloid administration improves the microcirculation of healthy and perianastomotic colon
AU - Kimberger, Oliver
AU - Arnberger, Michael
AU - Brandt, Sebastian
AU - Plock, Jan
AU - Sigurdsson, Gisli H.
AU - Kurz, Andrea
AU - Hiltebrand, Luzius
N1 - Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2009/3
Y1 - 2009/3
N2 - BACKGROUND: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS: Pigs (n = 27, 9 per group) were anesthetized and mechanically ventilated. A hand-sewn colon anastomosis was performed. The animals were subsequently randomized to one of the following treatments: R-RL group, 3 ml • kg • h Ringer lactate (RL); GD-RL group, 3 ml • kg • h RL + bolus 250 ml of RL; GD-C group, 3 ml • kg • h RL + bolus 250 ml of hydroxyethyl starch (HES 6%, 130/0.4). A fluid bolus was administered when mixed venous oxygen saturation dropped below 60%. Intestinal tissue oxygen tension and microcirculatory blood flow were measured continuously. RESULTS: After 4 h of treatment, tissue oxygen tension in healthy colon increased to 150 ± 31% in group GD-C versus 123 ± 40% in group GD-RL versus 94 ± 23% in group R-RL (percent of postoperative baseline values, mean ± SD; P < 0.01). Similarly perianastomotic tissue oxygen tension increased to 245 ± 93% in the GD-C group versus 147 ± 58% in the GD-RL group and 116 ± 22% in the R-RL group (P < 0.01). Microcirculatory flow was higher in group GD-C in healthy colon. CONCLUSIONS: Goal-directed colloid fluid therapy significantly increased microcirculatory blood flow and tissue oxygen tension in healthy and injured colon compared to goal-directed or restricted crystalloid fluid therapy.
AB - BACKGROUND: The aim of this study was to compare the effects of goal-directed colloid fluid therapy with goal-directed crystalloid and restricted crystalloid fluid therapy on healthy and perianastomotic colon tissue in a pig model of colon anastomosis surgery. METHODS: Pigs (n = 27, 9 per group) were anesthetized and mechanically ventilated. A hand-sewn colon anastomosis was performed. The animals were subsequently randomized to one of the following treatments: R-RL group, 3 ml • kg • h Ringer lactate (RL); GD-RL group, 3 ml • kg • h RL + bolus 250 ml of RL; GD-C group, 3 ml • kg • h RL + bolus 250 ml of hydroxyethyl starch (HES 6%, 130/0.4). A fluid bolus was administered when mixed venous oxygen saturation dropped below 60%. Intestinal tissue oxygen tension and microcirculatory blood flow were measured continuously. RESULTS: After 4 h of treatment, tissue oxygen tension in healthy colon increased to 150 ± 31% in group GD-C versus 123 ± 40% in group GD-RL versus 94 ± 23% in group R-RL (percent of postoperative baseline values, mean ± SD; P < 0.01). Similarly perianastomotic tissue oxygen tension increased to 245 ± 93% in the GD-C group versus 147 ± 58% in the GD-RL group and 116 ± 22% in the R-RL group (P < 0.01). Microcirculatory flow was higher in group GD-C in healthy colon. CONCLUSIONS: Goal-directed colloid fluid therapy significantly increased microcirculatory blood flow and tissue oxygen tension in healthy and injured colon compared to goal-directed or restricted crystalloid fluid therapy.
UR - http://www.scopus.com/inward/record.url?scp=62349083442&partnerID=8YFLogxK
U2 - 10.1097/ALN.0b013e31819841f6
DO - 10.1097/ALN.0b013e31819841f6
M3 - Journal articles
C2 - 19225390
AN - SCOPUS:62349083442
SN - 0003-3022
VL - 110
SP - 496
EP - 504
JO - Anesthesiology
JF - Anesthesiology
IS - 3
ER -