In this issue of Acta Physiologica, Gil-Iturbe et al. show how activity of the facilitative glucose transporter 12 (GLUT12, SLC2A12) in adipose tissues is regulated by metabolic signals such as insulin, leptin, adiponectin, tumour necrosis factor alpha (TNFα), and hypoxia. Using both in-vitro and in-vivo approaches the authors compare the hormonal modulation of GLUT12 expression and activity to that of GLUT4, the main insulin sensitive transporter responsible for glucose uptake. This article is protected by copyright. All rights reserved.