Glucocorticosteroid-resistant pemphigoid gestationis: Successful treatment with adjuvant immunoadsorption

Lilia Westermann, Rainer Haügel, Markus Meier, Michael Weichenthal, Detlef Zillikens, Regine Gläser, Enno Schmidt*

*Corresponding author for this work
8 Citations (Scopus)


A 40-year old prima para presented with multiple urticaria-like plaques and severe pruritus 2 weeks prior to giving birth by cesarean section. Three days after birth, the disease flared up and tense blisters appeared on hands, lower arms and feet. Based on the clinical presentation, direct immunofluorescence microscopy, complement binding test and detection of high levels of circulating anti-BP180 antibodies, the diagnosis of pemphigoid gestationis was established. Despite treatment with class IV topical corticosteroid and prednisolone p.o. up to 60 mg/day, both skin lesions and severe pruritus progressed accompanied by increasing anti-BP180 antibody serum levels. In order to continue breast feeding, the prednisolone dose could not be further increased and 10 immunoadsorptions over 4 weeks were performed. During this period, skin lesions cleared rapidly, pruritus subsided and BP180-specific serum autoantibodies decreased by 99.5% allowing the reduction of prednisolone to 7.5 mg/day. We conclude that immunoadsorption is an effective and safe adjuvant therapeutic option for severe pemphigoid gestationis.

Original languageEnglish
JournalJournal of Dermatology
Issue number2
Pages (from-to)168-171
Number of pages4
Publication statusPublished - 01.02.2012


Dive into the research topics of 'Glucocorticosteroid-resistant pemphigoid gestationis: Successful treatment with adjuvant immunoadsorption'. Together they form a unique fingerprint.

Cite this