Gilles de la Tourette Syndrom-Modellerkrankung verstärkter Kopplung zwischen Perzeption und Handlung?

Gilles de la Tourette syndrome is a common, multifaceted neuropsychiatric disorder characterized by multiple motor and vocal tics. Although numerous neuroanatomical and neurophysiological particularities have been documented, there is no general concept or overarching theory to explain the pathophysiology of Tourette syndrome. Given the premonitory urges that precede tics and the altered sensorimotor processing in Tourette syndrome, the "Theory of Event Coding" (TEC) seems to be an attractive framework. TEC assumes that perceptions and actions are bound together and encoded using the same neural code to form so-called "event fi les." Depending on the strength of the binding between perception and action, partial repetition of features of an event fi le can lead to increasing cost because existing event fi les need to be reconfi gured. This is referred to as "partial repetition costs", which appear to be increased in Tourette patients. This indicates stronger binding within "event fi les" in Tourette.