Ghrelin

T. D. Müller; R. Nogueiras; M. L. Andermann; Z. B. Andrews; S. D. Anker; J. Argente; R. L. Batterham; S. C. Benoit; C. Y. Bowers; F. Broglio; F. F. Casanueva; D. D'Alessio; I. Depoortere; A. Geliebter; E. Ghigo; P. A. Cole; M. Cowley; D. E. Cummings; A. Dagher; S. Diano; S. L. Dickson; C. Diéguez; R. Granata; H. J. Grill; K. Grove; K. M. Habegger; K. Heppner; M. L. Heiman; L. Holsen; B. Holst; A. Inui; J. O. Jansson; H. Kirchner; M. Korbonits; B. Laferrère; C. W. LeRoux; M. Lopez; S. Morin; M. Nakazato; R. Nass; D. Perez-Tilve; P. T. Pfluger; T. W. Schwartz; R. J. Seeley; M. Sleeman; Y. Sun; L. Sussel; J. Tong; M. O. Thorner; A. J. van der Lely

doi:10.1016/j.molmet.2015.03.005

Ghrelin

T. D. Müller, R. Nogueiras, M. L. Andermann, Z. B. Andrews, S. D. Anker, J. Argente, R. L. Batterham, S. C. Benoit, C. Y. Bowers, F. Broglio, F. F. Casanueva, D. D'Alessio, I. Depoortere, A. Geliebter, E. Ghigo, P. A. Cole, M. Cowley, D. E. Cummings, A. Dagher, S. DianoS. L. Dickson, C. Diéguez, R. Granata, H. J. Grill, K. Grove, K. M. Habegger, K. Heppner, M. L. Heiman, L. Holsen, B. Holst, A. Inui, J. O. Jansson, H. Kirchner, M. Korbonits, B. Laferrère, C. W. LeRoux, M. Lopez, S. Morin, M. Nakazato, R. Nass, D. Perez-Tilve, P. T. Pfluger, T. W. Schwartz, R. J. Seeley, M. Sleeman, Y. Sun, L. Sussel, J. Tong, M. O. Thorner, A. J. van der Lely

Department of Internal Medicine I

991 Citations (Scopus)

Abstract

The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

Original language	English
Journal	Molecular Metabolism
Volume	4
Issue number	6
Pages (from-to)	437-460
Number of pages	24
ISSN	2212-8778
DOIs	https://doi.org/10.1016/j.molmet.2015.03.005
Publication status	Published - 01.01.2015

Funding

This work was supported by grants from the NIH ( DP2DK105570-01 and 2P30DK046200 to MLA, DK21397 to HJG, K01DK098319 to KMH, K01MH091222 to LH, DK093848 to RJS, R01DK082590 to LS, R01DK097550 to JT, RO1 DK 076037 to MOT, R01DA024680 and R01MH085298 to JMZ, R01AG019230 and R01AG029740 to RGS) The Wellcome Trust (MK), Science Foundation Ireland ( 12/YI/B2480 to CWL), the Alexander von Humboldt Foundation (MHT), the Deutsches Zentrum für Diabetesforschung (MHT), the Helmholtz Alliance ICEMED – Imaging and Curing Environmental Metabolic Diseases , through the Initiative and Networking Fund of the Helmholtz Association (MHT), and the Helmholtz cross-program topic “Metabolic Dysfunction” (MHT). Allan Geliebter was sponsored by NIH grants R01DK80153 ; R01DK074046 ; R03DK068603 ; P30DK26687 .

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Müller, T. D., Nogueiras, R., Andermann, M. L., Andrews, Z. B., Anker, S. D., Argente, J., Batterham, R. L., Benoit, S. C., Bowers, C. Y., Broglio, F., Casanueva, F. F., D'Alessio, D., Depoortere, I., Geliebter, A., Ghigo, E., Cole, P. A., Cowley, M., Cummings, D. E., Dagher, A., ... van der Lely, A. J. (2015). Ghrelin. Molecular Metabolism, 4(6), 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

@article{cbcc64f6fcd745c6a1be0b8f3491de42,

title = "Ghrelin",

abstract = "The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.",

author = "M{\"u}ller, \{T. D.\} and R. Nogueiras and Andermann, \{M. L.\} and Andrews, \{Z. B.\} and Anker, \{S. D.\} and J. Argente and Batterham, \{R. L.\} and Benoit, \{S. C.\} and Bowers, \{C. Y.\} and F. Broglio and Casanueva, \{F. F.\} and D. D'Alessio and I. Depoortere and A. Geliebter and E. Ghigo and Cole, \{P. A.\} and M. Cowley and Cummings, \{D. E.\} and A. Dagher and S. Diano and Dickson, \{S. L.\} and C. Di{\'e}guez and R. Granata and Grill, \{H. J.\} and K. Grove and Habegger, \{K. M.\} and K. Heppner and Heiman, \{M. L.\} and L. Holsen and B. Holst and A. Inui and Jansson, \{J. O.\} and H. Kirchner and M. Korbonits and B. Laferr{\`e}re and LeRoux, \{C. W.\} and M. Lopez and S. Morin and M. Nakazato and R. Nass and D. Perez-Tilve and Pfluger, \{P. T.\} and Schwartz, \{T. W.\} and Seeley, \{R. J.\} and M. Sleeman and Y. Sun and L. Sussel and J. Tong and Thorner, \{M. O.\} and \{van der Lely\}, \{A. J.\}",

year = "2015",

month = jan,

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doi = "10.1016/j.molmet.2015.03.005",

language = "English",

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journal = "Molecular Metabolism",

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Müller, TD, Nogueiras, R, Andermann, ML, Andrews, ZB, Anker, SD, Argente, J, Batterham, RL, Benoit, SC, Bowers, CY, Broglio, F, Casanueva, FF, D'Alessio, D, Depoortere, I, Geliebter, A, Ghigo, E, Cole, PA, Cowley, M, Cummings, DE, Dagher, A, Diano, S, Dickson, SL, Diéguez, C, Granata, R, Grill, HJ, Grove, K, Habegger, KM, Heppner, K, Heiman, ML, Holsen, L, Holst, B, Inui, A, Jansson, JO, Kirchner, H, Korbonits, M, Laferrère, B, LeRoux, CW, Lopez, M, Morin, S, Nakazato, M, Nass, R, Perez-Tilve, D, Pfluger, PT, Schwartz, TW, Seeley, RJ, Sleeman, M, Sun, Y, Sussel, L, Tong, J, Thorner, MO & van der Lely, AJ 2015, 'Ghrelin', Molecular Metabolism, vol. 4, no. 6, pp. 437-460. https://doi.org/10.1016/j.molmet.2015.03.005

TY - JOUR

T1 - Ghrelin

AU - Müller, T. D.

AU - Nogueiras, R.

AU - Andermann, M. L.

AU - Andrews, Z. B.

AU - Anker, S. D.

AU - Argente, J.

AU - Batterham, R. L.

AU - Benoit, S. C.

AU - Bowers, C. Y.

AU - Broglio, F.

AU - Casanueva, F. F.

AU - D'Alessio, D.

AU - Depoortere, I.

AU - Geliebter, A.

AU - Ghigo, E.

AU - Cole, P. A.

AU - Cowley, M.

AU - Cummings, D. E.

AU - Dagher, A.

AU - Diano, S.

AU - Dickson, S. L.

AU - Diéguez, C.

AU - Granata, R.

AU - Grill, H. J.

AU - Grove, K.

AU - Habegger, K. M.

AU - Heppner, K.

AU - Heiman, M. L.

AU - Holsen, L.

AU - Holst, B.

AU - Inui, A.

AU - Jansson, J. O.

AU - Kirchner, H.

AU - Korbonits, M.

AU - Laferrère, B.

AU - LeRoux, C. W.

AU - Lopez, M.

AU - Morin, S.

AU - Nakazato, M.

AU - Nass, R.

AU - Perez-Tilve, D.

AU - Pfluger, P. T.

AU - Schwartz, T. W.

AU - Seeley, R. J.

AU - Sleeman, M.

AU - Sun, Y.

AU - Sussel, L.

AU - Tong, J.

AU - Thorner, M. O.

AU - van der Lely, A. J.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

AB - The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism. Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery. Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility and gastric acid secretion, sleep/wake rhythm, reward seeking behavior, taste sensation and glucose metabolism.

UR - https://www.scopus.com/pages/publications/84929964936

U2 - 10.1016/j.molmet.2015.03.005

DO - 10.1016/j.molmet.2015.03.005

M3 - Scientific review articles

AN - SCOPUS:84929964936

SN - 2212-8778

VL - 4

SP - 437

EP - 460

JO - Molecular Metabolism

JF - Molecular Metabolism

IS - 6

ER -

Ghrelin

Abstract

Funding

UN SDGs

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