TY - JOUR
T1 - Ghrelin serum concentrations are associated with treatment response during lithium augmentation of antidepressants
AU - Ricken, Roland
AU - Bopp, Sandra
AU - Schlattmann, Peter
AU - Himmerich, Hubertus
AU - Bschor, Tom
AU - Richter, Christoph
AU - Elstner, Samuel
AU - Stamm, Thomas J.
AU - Schulz-Ratei, Brigitte
AU - Lingesleben, Alexandra
AU - Reischies, Friedel M.
AU - Sterzer, Philipp
AU - Borgwardt, Stefan
AU - Bauer, Michael
AU - Heinz, Andreas
AU - Hellweg, Rainer
AU - Lang, Undine E.
AU - Adli, Mazda
N1 - Publisher Copyright:
© 2017 The Author.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Background: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation Method: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation. Results: In a linear mixed model analysis, we found a significant effect of response time interaction (F1.81 = 9.48; P = .0028): Under treatment, ghrelin levels increased in nonresponders and slightly decreased in responders to lithium augmentation. The covariate female gender had a significant positive effect (F1.83 = 4.69; P = .033), whereas time, response, appetite, and body mass index (kg/m2) did not show any significant effect on ghrelin levels (P > .05). Conclusion: This is the first study showing that the course of ghrelin levels separates responders and nonresponders to lithium augmentation. Present results support the hypothesis that ghrelin serum concentrations might be involved in response to pharmacological treatment of depression.
AB - Background: Lithium augmentation of antidepressants is an effective strategy in treatment-resistant depression. The proteohormone ghrelin is thought to be involved in the pathophysiology of depression. The purpose of this study was to investigate the association of treatment response with the course of ghrelin levels during lithium augmentation Method: Ghrelin serum concentrations and severity of depression were measured in 85 acute depressive patients before and after 4 weeks of lithium augmentation. Results: In a linear mixed model analysis, we found a significant effect of response time interaction (F1.81 = 9.48; P = .0028): Under treatment, ghrelin levels increased in nonresponders and slightly decreased in responders to lithium augmentation. The covariate female gender had a significant positive effect (F1.83 = 4.69; P = .033), whereas time, response, appetite, and body mass index (kg/m2) did not show any significant effect on ghrelin levels (P > .05). Conclusion: This is the first study showing that the course of ghrelin levels separates responders and nonresponders to lithium augmentation. Present results support the hypothesis that ghrelin serum concentrations might be involved in response to pharmacological treatment of depression.
UR - http://www.scopus.com/inward/record.url?scp=85037040767&partnerID=8YFLogxK
U2 - 10.1093/ijnp/pyw082
DO - 10.1093/ijnp/pyw082
M3 - Journal articles
C2 - 28911006
AN - SCOPUS:85037040767
SN - 1461-1457
VL - 20
SP - 692
EP - 697
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
IS - 9
ER -