Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma

Stephan Hellmig; Frank Gieseler; Stephan Ott; Phillip Rosenstiel; Wolfgang Fischbach; Ulrich Robert Fölsch; Stefan Schreiber

doi:10.1016/j.canlet.2005.07.017

Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma

Stephan Hellmig^*, Frank Gieseler, Stephan Ott, Phillip Rosenstiel, Wolfgang Fischbach, Ulrich Robert Fölsch, Stefan Schreiber

^*Corresponding author for this work

Clinic of Internal Medicine I

1 Citation (Scopus)

Abstract

We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.

Original language	English
Journal	Cancer Letters
Volume	238
Issue number	2
Pages (from-to)	295-303
Number of pages	9
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2005.07.017
Publication status	Published - 18.07.2006

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title = "Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma",

abstract = "We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.",

author = "Stephan Hellmig and Frank Gieseler and Stephan Ott and Phillip Rosenstiel and Wolfgang Fischbach and F{\"o}lsch, {Ulrich Robert} and Stefan Schreiber",

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T1 - Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma

AU - Hellmig, Stephan

AU - Gieseler, Frank

AU - Ott, Stephan

AU - Rosenstiel, Phillip

AU - Fischbach, Wolfgang

AU - Fölsch, Ulrich Robert

AU - Schreiber, Stefan

PY - 2006/7/18

Y1 - 2006/7/18

N2 - We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.

AB - We investigated if germline variations of the Topoisomerase II alpha gene could predispose patients with chronic Helicobacter pylori infection to develop gastric lymphoma and conducted a mutation detection of the entire promoter region. Single marker and haplotype analysis did not reveal any associations with development of gastric lymphoma in general, histological grade or stage of disease (P>0.05). No genetic variations in the promotor region were found in 92 chromosomes of lymphoma patients and controls and linkage disequilibrium indicated a highly conserved genomic region. The results of our work exclude genetic variations as predisposing factors of primary gastric B-cell lymphoma development.

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M3 - Journal articles

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AN - SCOPUS:33745050651

SN - 0304-3835

VL - 238

SP - 295

EP - 303

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

Germline variations of the topoisomerase IIα gene as risk factors for primary gastric B-cell lymphoma

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