Genomic profiling in triple-negative breast cancer

Cornelia Liedtke; Christof Bernemann; Ludwig Kiesel; Achim Rody

doi:10.1159/000357534

Genomic profiling in triple-negative breast cancer

Cornelia Liedtke^*
, Christof Bernemann
, Ludwig Kiesel
, Achim Rody

^*Corresponding author for this work

Department of Gynecology and Obstetrics

University of Münster

25 Citations (Scopus)

Abstract

Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of over-expression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.

Original language	English
Journal	Breast Care
Volume	8
Issue number	6
Pages (from-to)	408-413
Number of pages	6
ISSN	1661-3791
DOIs	https://doi.org/10.1159/000357534
Publication status	Published - 01.12.2013

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1159/000357534

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abstract = "Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of over-expression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.",

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AU - Bernemann, Christof

AU - Kiesel, Ludwig

AU - Rody, Achim

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N2 - Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of over-expression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.

AB - Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of over-expression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.

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M3 - Scientific review articles

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Genomic profiling in triple-negative breast cancer

Abstract

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