Genomic profiling in triple-negative breast cancer

Cornelia Liedtke*, Christof Bernemann, Ludwig Kiesel, Achim Rody

*Corresponding author for this work
14 Citations (Scopus)


Triple-negative breast cancer (TNBC) is defined by a lack of hormone receptor expression as well as lack of over-expression/amplification of HER2/neu. Patients with TNBC show a significantly worse prognosis compared to patients with other breast cancer subtypes. TNBC, however, is a heterogeneous entity both with regard to clinical/pathological characteristics and molecular biology. This review summarizes the current data on TNBC with a particular focus on mutational and gene expression profiling and the association between TNBC and breast cancer stem cells.

Original languageEnglish
JournalBreast Care
Issue number6
Pages (from-to)408-413
Number of pages6
Publication statusPublished - 01.12.2013


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