Genome-wide scan for Parkinson's disease: The GenePD study

A. L. DeStefano; L. I. Golbe; M. H. Mark; A. M. Lazzarini; N. E. Maher; M. Saint-Hilaire; R. G. Feldman; M. Guttman; R. L. Watts; O. Suchowersky; A. L. Lafontaine; N. Labelle; M. F. Lew; C. H. Waters; J. H. Growdon; C. Singer; L. J. Currie; G. F. Wooten; P. Vieregge; P. P. Pramstaller; C. Klein; J. P. Hubble; M. Stacy; E. Montgomery; M. E. MacDonald; J. F. Gusella; R. H. Myers

doi:10.1212/WNL.57.6.1124

Genome-wide scan for Parkinson's disease: The GenePD study

A. L. DeStefano
, L. I. Golbe
, M. H. Mark
, A. M. Lazzarini
, N. E. Maher
, M. Saint-Hilaire
, R. G. Feldman
, M. Guttman
, R. L. Watts
, O. Suchowersky
, A. L. Lafontaine
, N. Labelle
, M. F. Lew
, C. H. Waters
, J. H. Growdon
, C. Singer
, L. J. Currie
, G. F. Wooten
, P. Vieregge
, P. P. Pramstaller

C. Klein, J. P. Hubble, M. Stacy, E. Montgomery, M. E. MacDonald, J. F. Gusella, R. H. Myers^*

^*Corresponding author for this work

Institute of Neurogenetics

Department of Neurology
Boston University School of Medicine
University of Michigan
Department of Neurology
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School
University Health Network
Emory University
Departments of Clinical Neurosciences and Medical Genetics
University of Calgary
David Geffen School of Medicine at UCLA
University of Southern California
Harvard University
Department of Neurology
University of Miami
University of Virginia
European Academy Bozen
Department of Neurology
Ohio State University
Department of Neurology
Barrow Clinic
Departments of Neurology and Neuroscience
Cleveland Clinic Foundation

78 Citations (Scopus)

Abstract

A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

Original language	English
Journal	Neurology
Volume	57
Issue number	6
Pages (from-to)	1124-1126
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/WNL.57.6.1124
Publication status	Published - 25.09.2001

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1212/WNL.57.6.1124

Cite this

DeStefano, A. L., Golbe, L. I., Mark, M. H., Lazzarini, A. M., Maher, N. E., Saint-Hilaire, M., Feldman, R. G., Guttman, M., Watts, R. L., Suchowersky, O., Lafontaine, A. L., Labelle, N., Lew, M. F., Waters, C. H., Growdon, J. H., Singer, C., Currie, L. J., Wooten, G. F., Vieregge, P., ... Myers, R. H. (2001). Genome-wide scan for Parkinson's disease: The GenePD study. Neurology, 57(6), 1124-1126. https://doi.org/10.1212/WNL.57.6.1124

@article{57ad592ab85043bb9b7989be13c5ed36,

title = "Genome-wide scan for Parkinson's disease: The GenePD study",

abstract = "A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.",

author = "DeStefano, \{A. L.\} and Golbe, \{L. I.\} and Mark, \{M. H.\} and Lazzarini, \{A. M.\} and Maher, \{N. E.\} and M. Saint-Hilaire and Feldman, \{R. G.\} and M. Guttman and Watts, \{R. L.\} and O. Suchowersky and Lafontaine, \{A. L.\} and N. Labelle and Lew, \{M. F.\} and Waters, \{C. H.\} and Growdon, \{J. H.\} and C. Singer and Currie, \{L. J.\} and Wooten, \{G. F.\} and P. Vieregge and Pramstaller, \{P. P.\} and C. Klein and Hubble, \{J. P.\} and M. Stacy and E. Montgomery and MacDonald, \{M. E.\} and Gusella, \{J. F.\} and Myers, \{R. H.\}",

year = "2001",

month = sep,

day = "25",

doi = "10.1212/WNL.57.6.1124",

language = "English",

volume = "57",

pages = "1124--1126",

journal = "Neurology",

issn = "0028-3878",

number = "6",

}

DeStefano, AL, Golbe, LI, Mark, MH, Lazzarini, AM, Maher, NE, Saint-Hilaire, M, Feldman, RG, Guttman, M, Watts, RL, Suchowersky, O, Lafontaine, AL, Labelle, N, Lew, MF, Waters, CH, Growdon, JH, Singer, C, Currie, LJ, Wooten, GF, Vieregge, P, Pramstaller, PP, Klein, C, Hubble, JP, Stacy, M, Montgomery, E, MacDonald, ME, Gusella, JF & Myers, RH 2001, 'Genome-wide scan for Parkinson's disease: The GenePD study', Neurology, vol. 57, no. 6, pp. 1124-1126. https://doi.org/10.1212/WNL.57.6.1124

TY - JOUR

T1 - Genome-wide scan for Parkinson's disease: The GenePD study

AU - DeStefano, A. L.

AU - Golbe, L. I.

AU - Mark, M. H.

AU - Lazzarini, A. M.

AU - Maher, N. E.

AU - Saint-Hilaire, M.

AU - Feldman, R. G.

AU - Guttman, M.

AU - Watts, R. L.

AU - Suchowersky, O.

AU - Lafontaine, A. L.

AU - Labelle, N.

AU - Lew, M. F.

AU - Waters, C. H.

AU - Growdon, J. H.

AU - Singer, C.

AU - Currie, L. J.

AU - Wooten, G. F.

AU - Vieregge, P.

AU - Pramstaller, P. P.

AU - Klein, C.

AU - Hubble, J. P.

AU - Stacy, M.

AU - Montgomery, E.

AU - MacDonald, M. E.

AU - Gusella, J. F.

AU - Myers, R. H.

PY - 2001/9/25

Y1 - 2001/9/25

N2 - A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

AB - A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.

UR - https://www.scopus.com/pages/publications/0035949797

U2 - 10.1212/WNL.57.6.1124

DO - 10.1212/WNL.57.6.1124

M3 - Journal articles

AN - SCOPUS:0035949797

SN - 0028-3878

VL - 57

SP - 1124

EP - 1126

JO - Neurology

JF - Neurology

IS - 6

ER -

Genome-wide scan for Parkinson's disease: The GenePD study

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this