Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

David Alexandre Trégouët; Inke R. König; Jeanette Erdmann; Alexandru Munteanu; Peter S. Braund; Alistair S. Hall; Anika Großhennig; Patrick Linsel-Nitschke; Claire Perret; Maylis DeSuremain; Thomas Meitinger; Ben J. Wright; Michael Preuss; Anthony J. Balmforth; Stephen G. Ball; Christa Meisinger; Cécile Germain; Alun Evans; Dominique Arveiler; Gérald Luc; Jean Bernard Ruidavets; Caroline Morrison; Pim Van Der Harst; Stefan Schreiber; Katharina Neureuther; Arne Schäfer; Peter Bugert; Nour E. El Mokhtari; Jürgen Schrezenmeir; Klaus Stark; Diana Rubin; H. Erich Wichmann; Christian Hengstenberg; Willem Ouwehand; Andreas Ziegler; Laurence Tiret; John R. Thompson; Francois Cambien; Heribert Schunkert; Nilesh J. Samani

doi:10.1038/ng.314

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

David Alexandre Trégouët^*, Inke R. König, Jeanette Erdmann, Alexandru Munteanu, Peter S. Braund, Alistair S. Hall, Anika Großhennig, Patrick Linsel-Nitschke, Claire Perret, Maylis DeSuremain, Thomas Meitinger, Ben J. Wright, Michael Preuss, Anthony J. Balmforth, Stephen G. Ball, Christa Meisinger, Cécile Germain, Alun Evans, Dominique Arveiler, Gérald LucJean Bernard Ruidavets, Caroline Morrison, Pim Van Der Harst, Stefan Schreiber, Katharina Neureuther, Arne Schäfer, Peter Bugert, Nour E. El Mokhtari, Jürgen Schrezenmeir, Klaus Stark, Diana Rubin, H. Erich Wichmann, Christian Hengstenberg, Willem Ouwehand, Andreas Ziegler, Laurence Tiret, John R. Thompson, Francois Cambien, Heribert Schunkert, Nilesh J. Samani

^*Corresponding author for this work

309 Citations (Scopus)

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Original language	English
Journal	Nature Genetics
Volume	41
Issue number	3
Pages (from-to)	283-285
Number of pages	3
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.314
Publication status	Published - 01.03.2009

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Trégouët, D. A., König, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Großhennig, A., Linsel-Nitschke, P., Perret, C., DeSuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Balmforth, A. J., Ball, S. G., Meisinger, C., Germain, C., Evans, A., Arveiler, D., ... Samani, N. J. (2009). Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature Genetics, 41(3), 283-285. https://doi.org/10.1038/ng.314

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title = "Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease",

abstract = "We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.",

author = "Tr{\'e}gou{\"e}t, {David Alexandre} and K{\"o}nig, {Inke R.} and Jeanette Erdmann and Alexandru Munteanu and Braund, {Peter S.} and Hall, {Alistair S.} and Anika Gro{\ss}hennig and Patrick Linsel-Nitschke and Claire Perret and Maylis DeSuremain and Thomas Meitinger and Wright, {Ben J.} and Michael Preuss and Balmforth, {Anthony J.} and Ball, {Stephen G.} and Christa Meisinger and C{\'e}cile Germain and Alun Evans and Dominique Arveiler and G{\'e}rald Luc and Ruidavets, {Jean Bernard} and Caroline Morrison and {Van Der Harst}, Pim and Stefan Schreiber and Katharina Neureuther and Arne Sch{\"a}fer and Peter Bugert and {El Mokhtari}, {Nour E.} and J{\"u}rgen Schrezenmeir and Klaus Stark and Diana Rubin and Wichmann, {H. Erich} and Christian Hengstenberg and Willem Ouwehand and Andreas Ziegler and Laurence Tiret and Thompson, {John R.} and Francois Cambien and Heribert Schunkert and Samani, {Nilesh J.}",

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Trégouët, DA, König, IR, Erdmann, J, Munteanu, A, Braund, PS, Hall, AS, Großhennig, A, Linsel-Nitschke, P, Perret, C, DeSuremain, M, Meitinger, T, Wright, BJ, Preuss, M, Balmforth, AJ, Ball, SG, Meisinger, C, Germain, C, Evans, A, Arveiler, D, Luc, G, Ruidavets, JB, Morrison, C, Van Der Harst, P, Schreiber, S, Neureuther, K, Schäfer, A, Bugert, P, El Mokhtari, NE, Schrezenmeir, J, Stark, K, Rubin, D, Wichmann, HE, Hengstenberg, C, Ouwehand, W, Ziegler, A, Tiret, L, Thompson, JR, Cambien, F, Schunkert, H & Samani, NJ 2009, 'Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease', Nature Genetics, vol. 41, no. 3, pp. 283-285. https://doi.org/10.1038/ng.314

TY - JOUR

T1 - Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

AU - Trégouët, David Alexandre

AU - König, Inke R.

AU - Erdmann, Jeanette

AU - Munteanu, Alexandru

AU - Braund, Peter S.

AU - Hall, Alistair S.

AU - Großhennig, Anika

AU - Linsel-Nitschke, Patrick

AU - Perret, Claire

AU - DeSuremain, Maylis

AU - Meitinger, Thomas

AU - Wright, Ben J.

AU - Preuss, Michael

AU - Balmforth, Anthony J.

AU - Ball, Stephen G.

AU - Meisinger, Christa

AU - Germain, Cécile

AU - Evans, Alun

AU - Arveiler, Dominique

AU - Luc, Gérald

AU - Ruidavets, Jean Bernard

AU - Morrison, Caroline

AU - Van Der Harst, Pim

AU - Schreiber, Stefan

AU - Neureuther, Katharina

AU - Schäfer, Arne

AU - Bugert, Peter

AU - El Mokhtari, Nour E.

AU - Schrezenmeir, Jürgen

AU - Stark, Klaus

AU - Rubin, Diana

AU - Wichmann, H. Erich

AU - Hengstenberg, Christian

AU - Ouwehand, Willem

AU - Ziegler, Andreas

AU - Tiret, Laurence

AU - Thompson, John R.

AU - Cambien, Francois

AU - Schunkert, Heribert

AU - Samani, Nilesh J.

PY - 2009/3/1

Y1 - 2009/3/1

N2 - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

AB - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

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U2 - 10.1038/ng.314

DO - 10.1038/ng.314

M3 - Journal articles

C2 - 19198611

AN - SCOPUS:61349137526

SN - 1061-4036

VL - 41

SP - 283

EP - 285

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

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