TY - JOUR
T1 - Genome-wide association study of myocardial infarction, atrial fibrillation, acute stroke, acute kidney injury and delirium after cardiac surgery - A sub-analysis of the RIPHeart-Study
AU - Westphal, Sabine
AU - Stoppe, Christian
AU - Gruenewald, Matthias
AU - Bein, Berthold
AU - Renner, Jochen
AU - Cremer, Jochen
AU - Coburn, Mark
AU - Schaelte, Gereon
AU - Boening, Andreas
AU - Niemann, Bernd
AU - Kletzin, Frank
AU - Roesner, Jan
AU - Strouhal, Ulrich
AU - Reyher, Christian
AU - Laufenberg-Feldmann, Rita
AU - Ferner, Marion
AU - Brandes, Ivo F.
AU - Bauer, Martin
AU - Kortgen, Andreas
AU - Stehr, Sebastian N.
AU - Wittmann, Maria
AU - Baumgarten, Georg
AU - Struck, Rafael
AU - Meyer-Treschan, Tanja
AU - Kienbaum, Peter
AU - Heringlake, Matthias
AU - Schoen, Julika
AU - Sander, Michael
AU - Treskatsch, Sascha
AU - Smul, Thorsten
AU - Wolwender, Ewa
AU - Schilling, Thomas
AU - Degenhardt, Frauke
AU - Franke, Andre
AU - Mucha, Soeren
AU - Tittmann, Lukas
AU - Kohlhaas, Madeline
AU - Fuernau, Georg
AU - Brosteanu, Oana
AU - Hasenclever, Dirk
AU - Zacharowski, Kai
AU - Meybohm, Patrick
PY - 2019/1/24
Y1 - 2019/1/24
N2 - BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10
- 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10
- 5 from the GWAS.
CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.
AB - BACKGROUND: The aim of our study was the identification of genetic variants associated with postoperative complications after cardiac surgery.METHODS: We conducted a prospective, double-blind, multicenter, randomized trial (RIPHeart). We performed a genome-wide association study (GWAS) in 1170 patients of both genders (871 males, 299 females) from the RIPHeart-Study cohort. Patients undergoing non-emergent cardiac surgery were included. Primary endpoint comprises a binary composite complication rate covering atrial fibrillation, delirium, non-fatal myocardial infarction, acute renal failure and/or any new stroke until hospital discharge with a maximum of fourteen days after surgery.RESULTS: A total of 547,644 genotyped markers were available for analysis. Following quality control and adjustment for clinical covariate, one SNP reached genome-wide significance (PHLPP2, rs78064607, p = 3.77 × 10
- 8) and 139 (adjusted for all other outcomes) SNPs showed promising association with p < 1 × 10
- 5 from the GWAS.
CONCLUSIONS: We identified several potential loci, in particular PHLPP2, BBS9, RyR2, DUSP4 and HSPA8, associated with new-onset of atrial fibrillation, delirium, myocardial infarction, acute kidney injury and stroke after cardiac surgery.TRIAL REGISTRATION: The study was registered with ClinicalTrials.gov NCT01067703, prospectively registered on 11 Feb 2010.
UR - http://www.scopus.com/inward/record.url?scp=85060529420&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/genomewide-association-study-myocardial-infarction-atrial-fibrillation-acute-stroke-acute-kidney-inj
U2 - 10.1186/s12872-019-1002-x
DO - 10.1186/s12872-019-1002-x
M3 - Journal articles
C2 - 30678657
AN - SCOPUS:85060529420
SN - 1471-2261
VL - 19
SP - 26
JO - BMC cardiovascular disorders
JF - BMC cardiovascular disorders
IS - 1
M1 - 1002
ER -