Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Xiangfeng Lu; Laiyuan Wang; Shufeng Chen; Lin He; Xueli Yang; Yongyong Shi; Jing Cheng; Liang Zhang; C. Charles Gu; Jianfeng Huang; Tangchun Wu; Yitong Ma; Jianxin Li; Jie Cao; Jichun Chen; Dongliang Ge; Zhongjie Fan; Ying Li; Liancheng Zhao; Hongfan Li; Xiaoyang Zhou; Lanying Chen; Donghua Liu; Jingping Chen; Xiufang Duan; Yongchen Hao; Ligui Wang; Fanghong Lu; Zhendong Liu; Cailiang Yao; Chong Shen; Xiaodong Pu; Lin Yu; Xianghua Fang; Lihua Xu; Jianjun Mu; Xianping Wu; Runping Zheng; Naqiong Wu; Qi Zhao; Yun Li; Xiaoli Liu; Mengqin Wang; Dahai Yu; Dongsheng Hu; Xu Ji; Dongshuang Guo; Dongling Sun; Qianqian Wang; Ying Yang; Fangchao Liu; Qunxia Mao; Xiaohua Liang; Jingfeng Ji; Panpan Chen; Xingbo Mo; Dianjiang Li; Guoping Chai; Yida Tang; Xiangdong Li; Zhenhan Du; Xuehui Liu; Chenlong Dou; Zili Yang; Qingjie Meng; Dong Wang; Renping Wang; Jun Yang; Heribert Schunkert; Nilesh J. Samani; Sekar Kathiresan; Muredach P. Reilly; Jeanette Erdmann; Xiaozhong Peng; Xigui Wu; Depei Liu; Yuejin Yang; Runsheng Chen; Boqin Qiang; Dongfeng Gu

doi:10.1038/ng.2337

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Xiangfeng Lu, Laiyuan Wang, Shufeng Chen, Lin He, Xueli Yang, Yongyong Shi, Jing Cheng, Liang Zhang, C. Charles Gu, Jianfeng Huang, Tangchun Wu, Yitong Ma, Jianxin Li, Jie Cao, Jichun Chen, Dongliang Ge, Zhongjie Fan, Ying Li, Liancheng Zhao, Hongfan LiXiaoyang Zhou, Lanying Chen, Donghua Liu, Jingping Chen, Xiufang Duan, Yongchen Hao, Ligui Wang, Fanghong Lu, Zhendong Liu, Cailiang Yao, Chong Shen, Xiaodong Pu, Lin Yu, Xianghua Fang, Lihua Xu, Jianjun Mu, Xianping Wu, Runping Zheng, Naqiong Wu, Qi Zhao, Yun Li, Xiaoli Liu, Mengqin Wang, Dahai Yu, Dongsheng Hu, Xu Ji, Dongshuang Guo, Dongling Sun, Qianqian Wang, Ying Yang, Fangchao Liu, Qunxia Mao, Xiaohua Liang, Jingfeng Ji, Panpan Chen, Xingbo Mo, Dianjiang Li, Guoping Chai, Yida Tang, Xiangdong Li, Zhenhan Du, Xuehui Liu, Chenlong Dou, Zili Yang, Qingjie Meng, Dong Wang, Renping Wang, Jun Yang, Heribert Schunkert, Nilesh J. Samani, Sekar Kathiresan, Muredach P. Reilly, Jeanette Erdmann, Xiaozhong Peng, Xigui Wu, Depei Liu, Yuejin Yang, Runsheng Chen, Boqin Qiang, Dongfeng Gu^*

^*Corresponding author for this work

Clinic of Internal Medicine II - Cardiology

280 Citations (Scopus)

Abstract

We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10^-8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

Original language	English
Journal	Nature Genetics
Volume	44
Issue number	8
Pages (from-to)	890-894
Number of pages	5
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.2337
Publication status	Published - 01.08.2012

Funding

This study was funded by the National Basic Research Program of China (973 Plan) (2011CB503901 and 2006CB503805) from the Ministry of Science and Technology of China, by the National Science Foundation of China (30930047), by the High-Tech Research and Development Program of China (863 Plan) (2009AA022703, 2012AA02A516 and 2006AA02A406) and by a grant from the Ministry of Science and Technology of China (2006BAI01A01). This study was also supported by Biomedical Project from the Council of Science and Technology, Beijing (H020220030130).

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Lu, X., Wang, L., Chen, S., He, L., Yang, X., Shi, Y., Cheng, J., Zhang, L., Gu, C. C., Huang, J., Wu, T., Ma, Y., Li, J., Cao, J., Chen, J., Ge, D., Fan, Z., Li, Y., Zhao, L., ... Gu, D. (2012). Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease. Nature Genetics, 44(8), 890-894. https://doi.org/10.1038/ng.2337

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title = "Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease",

abstract = "We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10-8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.",

author = "Xiangfeng Lu and Laiyuan Wang and Shufeng Chen and Lin He and Xueli Yang and Yongyong Shi and Jing Cheng and Liang Zhang and Gu, \{C. Charles\} and Jianfeng Huang and Tangchun Wu and Yitong Ma and Jianxin Li and Jie Cao and Jichun Chen and Dongliang Ge and Zhongjie Fan and Ying Li and Liancheng Zhao and Hongfan Li and Xiaoyang Zhou and Lanying Chen and Donghua Liu and Jingping Chen and Xiufang Duan and Yongchen Hao and Ligui Wang and Fanghong Lu and Zhendong Liu and Cailiang Yao and Chong Shen and Xiaodong Pu and Lin Yu and Xianghua Fang and Lihua Xu and Jianjun Mu and Xianping Wu and Runping Zheng and Naqiong Wu and Qi Zhao and Yun Li and Xiaoli Liu and Mengqin Wang and Dahai Yu and Dongsheng Hu and Xu Ji and Dongshuang Guo and Dongling Sun and Qianqian Wang and Ying Yang and Fangchao Liu and Qunxia Mao and Xiaohua Liang and Jingfeng Ji and Panpan Chen and Xingbo Mo and Dianjiang Li and Guoping Chai and Yida Tang and Xiangdong Li and Zhenhan Du and Xuehui Liu and Chenlong Dou and Zili Yang and Qingjie Meng and Dong Wang and Renping Wang and Jun Yang and Heribert Schunkert and Samani, \{Nilesh J.\} and Sekar Kathiresan and Reilly, \{Muredach P.\} and Jeanette Erdmann and Xiaozhong Peng and Xigui Wu and Depei Liu and Yuejin Yang and Runsheng Chen and Boqin Qiang and Dongfeng Gu",

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Lu, X, Wang, L, Chen, S, He, L, Yang, X, Shi, Y, Cheng, J, Zhang, L, Gu, CC, Huang, J, Wu, T, Ma, Y, Li, J, Cao, J, Chen, J, Ge, D, Fan, Z, Li, Y, Zhao, L, Li, H, Zhou, X, Chen, L, Liu, D, Chen, J, Duan, X, Hao, Y, Wang, L, Lu, F, Liu, Z, Yao, C, Shen, C, Pu, X, Yu, L, Fang, X, Xu, L, Mu, J, Wu, X, Zheng, R, Wu, N, Zhao, Q, Li, Y, Liu, X, Wang, M, Yu, D, Hu, D, Ji, X, Guo, D, Sun, D, Wang, Q, Yang, Y, Liu, F, Mao, Q, Liang, X, Ji, J, Chen, P, Mo, X, Li, D, Chai, G, Tang, Y, Li, X, Du, Z, Liu, X, Dou, C, Yang, Z, Meng, Q, Wang, D, Wang, R, Yang, J, Schunkert, H, Samani, NJ, Kathiresan, S, Reilly, MP, Erdmann, J, Peng, X, Wu, X, Liu, D, Yang, Y, Chen, R, Qiang, B & Gu, D 2012, 'Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease', Nature Genetics, vol. 44, no. 8, pp. 890-894. https://doi.org/10.1038/ng.2337

TY - JOUR

T1 - Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

AU - Lu, Xiangfeng

AU - Wang, Laiyuan

AU - Chen, Shufeng

AU - He, Lin

AU - Yang, Xueli

AU - Shi, Yongyong

AU - Cheng, Jing

AU - Zhang, Liang

AU - Gu, C. Charles

AU - Huang, Jianfeng

AU - Wu, Tangchun

AU - Ma, Yitong

AU - Li, Jianxin

AU - Cao, Jie

AU - Chen, Jichun

AU - Ge, Dongliang

AU - Fan, Zhongjie

AU - Li, Ying

AU - Zhao, Liancheng

AU - Li, Hongfan

AU - Zhou, Xiaoyang

AU - Chen, Lanying

AU - Liu, Donghua

AU - Chen, Jingping

AU - Duan, Xiufang

AU - Hao, Yongchen

AU - Wang, Ligui

AU - Lu, Fanghong

AU - Liu, Zhendong

AU - Yao, Cailiang

AU - Shen, Chong

AU - Pu, Xiaodong

AU - Yu, Lin

AU - Fang, Xianghua

AU - Xu, Lihua

AU - Mu, Jianjun

AU - Wu, Xianping

AU - Zheng, Runping

AU - Wu, Naqiong

AU - Zhao, Qi

AU - Li, Yun

AU - Liu, Xiaoli

AU - Wang, Mengqin

AU - Yu, Dahai

AU - Hu, Dongsheng

AU - Ji, Xu

AU - Guo, Dongshuang

AU - Sun, Dongling

AU - Wang, Qianqian

AU - Yang, Ying

AU - Liu, Fangchao

AU - Mao, Qunxia

AU - Liang, Xiaohua

AU - Ji, Jingfeng

AU - Chen, Panpan

AU - Mo, Xingbo

AU - Li, Dianjiang

AU - Chai, Guoping

AU - Tang, Yida

AU - Li, Xiangdong

AU - Du, Zhenhan

AU - Liu, Xuehui

AU - Dou, Chenlong

AU - Yang, Zili

AU - Meng, Qingjie

AU - Wang, Dong

AU - Wang, Renping

AU - Yang, Jun

AU - Schunkert, Heribert

AU - Samani, Nilesh J.

AU - Kathiresan, Sekar

AU - Reilly, Muredach P.

AU - Erdmann, Jeanette

AU - Peng, Xiaozhong

AU - Wu, Xigui

AU - Liu, Depei

AU - Yang, Yuejin

AU - Chen, Runsheng

AU - Qiang, Boqin

AU - Gu, Dongfeng

PY - 2012/8/1

Y1 - 2012/8/1

N2 - We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10-8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

AB - We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10-8). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.

UR - https://www.scopus.com/pages/publications/84864407698

U2 - 10.1038/ng.2337

DO - 10.1038/ng.2337

M3 - Journal articles

AN - SCOPUS:84864407698

SN - 1061-4036

VL - 44

SP - 890

EP - 894

JO - Nature Genetics

JF - Nature Genetics

IS - 8

ER -

Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease

Abstract

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