Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

Juliane Winkelmann; Oli Polo; Federica Provini; Sonja Nevsimalova; David Kemlink; Karel Sonka; Birgit Högl; Werner Poewe; Karin Stiasny-Kolster; Wolfgang Oertel; Al De Weerd; Luigi Ferini Strambi; Marco Zucconi; Peter P. Pramstaller; Isabelle Arnulf; Claudia Trenkwalder; Christine Klein; Georgios M. Hadjigeorgiou; Svenja Happe; David Rye; Pasquale Montagna

doi:10.1002/mds.21587

Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

Juliane Winkelmann^*, Oli Polo, Federica Provini, Sonja Nevsimalova, David Kemlink, Karel Sonka, Birgit Högl, Werner Poewe, Karin Stiasny-Kolster, Wolfgang Oertel, Al De Weerd, Luigi Ferini Strambi, Marco Zucconi, Peter P. Pramstaller, Isabelle Arnulf, Claudia Trenkwalder, Christine Klein, Georgios M. Hadjigeorgiou, Svenja Happe, David RyePasquale Montagna

^*Corresponding author for this work

Institute of Neurogenetics

63 Citations (Scopus)

Abstract

Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.

Original language	English
Journal	Movement Disorders
Volume	22
Issue number	SUPPL. 18
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.21587
Publication status	Published - 01.12.2007

Research Areas and Centers

Research Area: Medical Genetics

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mds.21587

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Winkelmann, J., Polo, O., Provini, F., Nevsimalova, S., Kemlink, D., Sonka, K., Högl, B., Poewe, W., Stiasny-Kolster, K., Oertel, W., De Weerd, A., Strambi, L. F., Zucconi, M., Pramstaller, P. P., Arnulf, I., Trenkwalder, C., Klein, C., Hadjigeorgiou, G. M., Happe, S., ... Montagna, P. (2007). Genetics of restless legs syndrome (RLS): State-of-the-art and future directions. Movement Disorders, 22(SUPPL. 18). https://doi.org/10.1002/mds.21587

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title = "Genetics of restless legs syndrome (RLS): State-of-the-art and future directions",

abstract = "Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.",

author = "Juliane Winkelmann and Oli Polo and Federica Provini and Sonja Nevsimalova and David Kemlink and Karel Sonka and Birgit H{\"o}gl and Werner Poewe and Karin Stiasny-Kolster and Wolfgang Oertel and {De Weerd}, Al and Strambi, {Luigi Ferini} and Marco Zucconi and Pramstaller, {Peter P.} and Isabelle Arnulf and Claudia Trenkwalder and Christine Klein and Hadjigeorgiou, {Georgios M.} and Svenja Happe and David Rye and Pasquale Montagna",

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Winkelmann, J, Polo, O, Provini, F, Nevsimalova, S, Kemlink, D, Sonka, K, Högl, B, Poewe, W, Stiasny-Kolster, K, Oertel, W, De Weerd, A, Strambi, LF, Zucconi, M, Pramstaller, PP, Arnulf, I, Trenkwalder, C, Klein, C, Hadjigeorgiou, GM, Happe, S, Rye, D & Montagna, P 2007, 'Genetics of restless legs syndrome (RLS): State-of-the-art and future directions', Movement Disorders, vol. 22, no. SUPPL. 18. https://doi.org/10.1002/mds.21587

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T1 - Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

AU - Winkelmann, Juliane

AU - Polo, Oli

AU - Provini, Federica

AU - Nevsimalova, Sonja

AU - Kemlink, David

AU - Sonka, Karel

AU - Högl, Birgit

AU - Poewe, Werner

AU - Stiasny-Kolster, Karin

AU - Oertel, Wolfgang

AU - De Weerd, Al

AU - Strambi, Luigi Ferini

AU - Zucconi, Marco

AU - Pramstaller, Peter P.

AU - Arnulf, Isabelle

AU - Trenkwalder, Claudia

AU - Klein, Christine

AU - Hadjigeorgiou, Georgios M.

AU - Happe, Svenja

AU - Rye, David

AU - Montagna, Pasquale

PY - 2007/12/1

Y1 - 2007/12/1

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AB - Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive family history and it has been suggested that RLS is a highly hereditary trait. To date, several loci have been mapped but no gene has been identified yet. Phenocopies and possible nonpenetrants made it difficult to detect a common segregating haplotype within the families. Defining the exact candidate region is hampered by possible intrafamilial, allelic, and nonallelic heterogeneity. One important prerequisite for future successful genetic studies in RLS is the availability of large and thoroughly phenotyped patients and family samples for linkage as well as association studies.

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SN - 0885-3185

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JO - Movement Disorders

JF - Movement Disorders

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Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

Abstract

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Identification of genetic causes of restless legs syndrome

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Genetics of restless legs syndrome (RLS): State-of-the-art and future directions

Abstract

Research Areas and Centers

UN SDGs

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Identification of genetic causes of restless legs syndrome

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