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Genetics and heritability of coronary artery disease and myocardial infarction

Björn Mayer*, Jeanette Erdmann, Heribert Schunkert

*Corresponding author for this work

Abstract

A positive family history is frequently reported by patients with coronary artery disease (CAD) or myocardial infarction. For risk stratification, it is crucial to distinguish between accidental reoccurrence of sporadic cases and cases with a true heritable component of the conditions. A familial predisposition is assumed when a myocardial infarction is diagnosed by a male first degree relative before the 55th year of life or a female first degree relative before the 65th year of life. The current manuscript reviews major studies from which a familial risk of CAD or myocardial infarction can be inferred. Moreover, a brief overview summarizes the current results of molecular genetic research on chromosomal loci and genes relevant for CAD and myocardial infarction.

Original languageEnglish
JournalClinical Research in Cardiology
Volume96
Issue number1
Pages (from-to)1-7
Number of pages7
ISSN1861-0684
DOIs
Publication statusPublished - 01.01.2007

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being
  2. SDG 5 - Gender Equality
    SDG 5 Gender Equality

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