Genetic Instability and Disease Prognostication

Timo Gemoll, Gert Auer, Thomas Ried, Jens K Habermann


Genetic instability is a striking feature of human cancers, with an impact on the genesis, progression and prognosis. The clinical importance of genomic instability and aneuploidy is underscored by its association with poor patient outcome in multiple cancer types, including breast and colon cancer. Interestingly, there is growing evidence that prognostic gene expression signatures simply reflect the degree of genomic instability. Additionally, also the proteome is affected by aneuploidy and has therefore become a powerful tool to screen for new targets for therapy, diagnosis and prognostication. In this context, the chapter presents the impact of genomic instability on disease prognostication occurring in human cancers.

Original languageEnglish
JournalRecent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer
Pages (from-to)81-94
Number of pages14
Publication statusPublished - 2015


Dive into the research topics of 'Genetic Instability and Disease Prognostication'. Together they form a unique fingerprint.

Cite this