Genetic history of an archaic hominin group from Denisova cave in Siberia

David Reich; Richard E. Green; Martin Kircher; Johannes Krause; Nick Patterson; Eric Y. Durand; Bence Viola; Adrian W. Briggs; Udo Stenzel; Philip L.F. Johnson; Tomislav Maricic; Jeffrey M. Good; Tomas Marques-Bonet; Can Alkan; Qiaomei Fu; Swapan Mallick; Heng Li; Matthias Meyer; Evan E. Eichler; Mark Stoneking; Michael Richards; Sahra Talamo; Michael V. Shunkov; Anatoli P. Derevianko; Jean Jacques Hublin; Janet Kelso; Montgomery Slatkin; Svante Pääbo

doi:10.1038/nature09710

Genetic history of an archaic hominin group from Denisova cave in Siberia

David Reich^*, Richard E. Green, Martin Kircher, Johannes Krause, Nick Patterson, Eric Y. Durand, Bence Viola, Adrian W. Briggs, Udo Stenzel, Philip L.F. Johnson, Tomislav Maricic, Jeffrey M. Good, Tomas Marques-Bonet, Can Alkan, Qiaomei Fu, Swapan Mallick, Heng Li, Matthias Meyer, Evan E. Eichler, Mark StonekingMichael Richards, Sahra Talamo, Michael V. Shunkov, Anatoli P. Derevianko, Jean Jacques Hublin, Janet Kelso, Montgomery Slatkin, Svante Pääbo

^*Corresponding author for this work

Institute of Human Genetics

1444 Citations (Scopus)

Abstract

Using DNA extracted froma finger bone found in Denisova Cave in southern Siberia, wehave sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed4-6%of its genetic material to the genomes of present-day Melanesians.Wedesignate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch.Atooth found in Denisova Cave carries a mitochondrialgenome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

Original language	English
Journal	Nature
Volume	468
Issue number	7327
Pages (from-to)	1053-1060
Number of pages	8
ISSN	0028-0836
DOIs	https://doi.org/10.1038/nature09710
Publication status	Published - 23.12.2010

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Reich, D., Green, R. E., Kircher, M., Krause, J., Patterson, N., Durand, E. Y., Viola, B., Briggs, A. W., Stenzel, U., Johnson, P. L. F., Maricic, T., Good, J. M., Marques-Bonet, T., Alkan, C., Fu, Q., Mallick, S., Li, H., Meyer, M., Eichler, E. E., ... Pääbo, S. (2010). Genetic history of an archaic hominin group from Denisova cave in Siberia. Nature, 468(7327), 1053-1060. https://doi.org/10.1038/nature09710

@article{9db898ee8ec840e497e8164094e8ce91,

title = "Genetic history of an archaic hominin group from Denisova cave in Siberia",

abstract = "Using DNA extracted froma finger bone found in Denisova Cave in southern Siberia, wehave sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed4-6\%of its genetic material to the genomes of present-day Melanesians.Wedesignate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch.Atooth found in Denisova Cave carries a mitochondrialgenome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.",

author = "David Reich and Green, \{Richard E.\} and Martin Kircher and Johannes Krause and Nick Patterson and Durand, \{Eric Y.\} and Bence Viola and Briggs, \{Adrian W.\} and Udo Stenzel and Johnson, \{Philip L.F.\} and Tomislav Maricic and Good, \{Jeffrey M.\} and Tomas Marques-Bonet and Can Alkan and Qiaomei Fu and Swapan Mallick and Heng Li and Matthias Meyer and Eichler, \{Evan E.\} and Mark Stoneking and Michael Richards and Sahra Talamo and Shunkov, \{Michael V.\} and Derevianko, \{Anatoli P.\} and Hublin, \{Jean Jacques\} and Janet Kelso and Montgomery Slatkin and Svante P{\"a}{\"a}bo",

year = "2010",

month = dec,

day = "23",

doi = "10.1038/nature09710",

language = "English",

volume = "468",

pages = "1053--1060",

journal = "Nature",

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Reich, D, Green, RE, Kircher, M, Krause, J, Patterson, N, Durand, EY, Viola, B, Briggs, AW, Stenzel, U, Johnson, PLF, Maricic, T, Good, JM, Marques-Bonet, T, Alkan, C, Fu, Q, Mallick, S, Li, H, Meyer, M, Eichler, EE, Stoneking, M, Richards, M, Talamo, S, Shunkov, MV, Derevianko, AP, Hublin, JJ, Kelso, J, Slatkin, M & Pääbo, S 2010, 'Genetic history of an archaic hominin group from Denisova cave in Siberia', Nature, vol. 468, no. 7327, pp. 1053-1060. https://doi.org/10.1038/nature09710

TY - JOUR

T1 - Genetic history of an archaic hominin group from Denisova cave in Siberia

AU - Reich, David

AU - Green, Richard E.

AU - Kircher, Martin

AU - Krause, Johannes

AU - Patterson, Nick

AU - Durand, Eric Y.

AU - Viola, Bence

AU - Briggs, Adrian W.

AU - Stenzel, Udo

AU - Johnson, Philip L.F.

AU - Maricic, Tomislav

AU - Good, Jeffrey M.

AU - Marques-Bonet, Tomas

AU - Alkan, Can

AU - Fu, Qiaomei

AU - Mallick, Swapan

AU - Li, Heng

AU - Meyer, Matthias

AU - Eichler, Evan E.

AU - Stoneking, Mark

AU - Richards, Michael

AU - Talamo, Sahra

AU - Shunkov, Michael V.

AU - Derevianko, Anatoli P.

AU - Hublin, Jean Jacques

AU - Kelso, Janet

AU - Slatkin, Montgomery

AU - Pääbo, Svante

PY - 2010/12/23

Y1 - 2010/12/23

N2 - Using DNA extracted froma finger bone found in Denisova Cave in southern Siberia, wehave sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed4-6%of its genetic material to the genomes of present-day Melanesians.Wedesignate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch.Atooth found in Denisova Cave carries a mitochondrialgenome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

AB - Using DNA extracted froma finger bone found in Denisova Cave in southern Siberia, wehave sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed4-6%of its genetic material to the genomes of present-day Melanesians.Wedesignate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch.Atooth found in Denisova Cave carries a mitochondrialgenome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.

UR - https://www.scopus.com/pages/publications/78650850475

U2 - 10.1038/nature09710

DO - 10.1038/nature09710

M3 - Journal articles

C2 - 21179161

AN - SCOPUS:78650850475

SN - 0028-0836

VL - 468

SP - 1053

EP - 1060

JO - Nature

JF - Nature

IS - 7327

ER -

Genetic history of an archaic hominin group from Denisova cave in Siberia

Abstract

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