TY - JOUR
T1 - Genetic Control of Spontaneous Arthritis in a Four-Way Advanced Intercross Line
AU - Ranea, Laura Mellado
AU - de Castro Marques, Andreia
AU - Möller, Steffen
AU - Gupta, Yask
AU - Ibrahim, Saleh M.
PY - 2013/10/11
Y1 - 2013/10/11
N2 - Identifying the genetic basis of complex diseases, such as rheumatoid arthritis, remains a challenge that requires experimental models to reduce the genetic and environmental variability. Numerous loci for arthritis have been identified in induced animal models; however, few spontaneous models have been genetically studied. Therefore, we generated a four-way advanced intercross line (AIL) from four inbred strains, including BXD2/TyJ which spontaneously develops autoimmune arthritis. A genome-wide scan for spontaneous arthritis was performed in a cohort of 366 mice of the fourth generation (G4) of this cross. Five loci contributing to clinical phenotypes were identified in chromosomes 3, 7, 13, 18, and X. Three of the loci found in this study, confirm previously identified loci; whereas two of them are novel loci. Interesting candidate genes for the loci are highlighted. This study provides a genetic overview of spontaneous arthritis in mice and aids to solve the genetic etiology of rheumatoid arthritis and to gain a better understanding of the disease.
AB - Identifying the genetic basis of complex diseases, such as rheumatoid arthritis, remains a challenge that requires experimental models to reduce the genetic and environmental variability. Numerous loci for arthritis have been identified in induced animal models; however, few spontaneous models have been genetically studied. Therefore, we generated a four-way advanced intercross line (AIL) from four inbred strains, including BXD2/TyJ which spontaneously develops autoimmune arthritis. A genome-wide scan for spontaneous arthritis was performed in a cohort of 366 mice of the fourth generation (G4) of this cross. Five loci contributing to clinical phenotypes were identified in chromosomes 3, 7, 13, 18, and X. Three of the loci found in this study, confirm previously identified loci; whereas two of them are novel loci. Interesting candidate genes for the loci are highlighted. This study provides a genetic overview of spontaneous arthritis in mice and aids to solve the genetic etiology of rheumatoid arthritis and to gain a better understanding of the disease.
UR - http://www.scopus.com/inward/record.url?scp=84885404846&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0075611
DO - 10.1371/journal.pone.0075611
M3 - Journal articles
C2 - 24146764
AN - SCOPUS:84885404846
SN - 1553-7390
VL - 8
JO - PLoS ONE
JF - PLoS ONE
IS - 10
M1 - e75611
ER -
