Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

Aleksandar Rakovic; Barbara Stiller; Ana Djarmati; Antonia Flaquer; Jan Freudenberg; Mohammad Reza Toliat; Michael Linnebank; Vladimir Kostic; Katja Lohmann; Sebastian Paus; Peter Nürnberg; Christian Kubisch; Christine Klein; Ullrich Wüllner; Alfredo Ramirez

doi:10.1002/mds.22399

Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

Aleksandar Rakovic, Barbara Stiller, Ana Djarmati, Antonia Flaquer, Jan Freudenberg, Mohammad Reza Toliat, Michael Linnebank, Vladimir Kostic, Katja Lohmann, Sebastian Paus, Peter Nürnberg, Christian Kubisch, Christine Klein, Ullrich Wüllner, Alfredo Ramirez^*

^*Corresponding author for this work

11 Citations (Scopus)

Abstract

A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P_UNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.

Original language	English
Journal	Movement Disorders
Volume	24
Issue number	3
Pages (from-to)	429-433
Number of pages	5
ISSN	0885-3185
DOIs	https://doi.org/10.1002/mds.22399
Publication status	Published - 15.02.2009

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title = "Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease",

abstract = "A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (PUNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.",

author = "Aleksandar Rakovic and Barbara Stiller and Ana Djarmati and Antonia Flaquer and Jan Freudenberg and Toliat, {Mohammad Reza} and Michael Linnebank and Vladimir Kostic and Katja Lohmann and Sebastian Paus and Peter N{\"u}rnberg and Christian Kubisch and Christine Klein and Ullrich W{\"u}llner and Alfredo Ramirez",

year = "2009",

month = feb,

day = "15",

doi = "10.1002/mds.22399",

language = "English",

volume = "24",

pages = "429--433",

journal = "Movement Disorders",

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TY - JOUR

T1 - Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

AU - Rakovic, Aleksandar

AU - Stiller, Barbara

AU - Djarmati, Ana

AU - Flaquer, Antonia

AU - Freudenberg, Jan

AU - Toliat, Mohammad Reza

AU - Linnebank, Michael

AU - Kostic, Vladimir

AU - Lohmann, Katja

AU - Paus, Sebastian

AU - Nürnberg, Peter

AU - Kubisch, Christian

AU - Klein, Christine

AU - Wüllner, Ullrich

AU - Ramirez, Alfredo

PY - 2009/2/15

Y1 - 2009/2/15

N2 - A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (PUNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.

AB - A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (PUNC = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.

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U2 - 10.1002/mds.22399

DO - 10.1002/mds.22399

M3 - Journal articles

C2 - 19097176

AN - SCOPUS:67651107343

VL - 24

SP - 429

EP - 433

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 3

ER -

Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease

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