Genetic and Environmental Risk Factors of Autoimmune Bullous Diseases

Enno Schmidt*, Luca Borradori, Eli Sprecher, Branka Marinovic, Animesh A. Sinha, Pascal Joly

*Corresponding author for this work


Nuclear medicine imaging is key in the initial diagnostic workup and used for staging and restaging. Also it forms basis for planning of therapy targeting somatostatin receptors, either as somatostatin analogues or peptide receptor radionuclide therapy (PRRT). For decades somatostatin receptor scintigraphy has successfully been performed using gamma camera technique and SPECT with the tracer 111In-DTPA-octreotide. Recently, several positron emission tomography (PET) tracers targeting the somatostatin receptors have been introduced. The most commonly used of these are 68Ga-DOTATATE, 68Ga-DOTATOC, and 68Ga-DOTANOC. They all perform superior to SPECT and should replace gamma camera tracers whenever possible. With FDG-PET it is possible to detect a large proportion of the somatostatin receptor-negative cases, and FDG-PET therefore seems to be a valuable addition. Furthermore, FDG-PET has prognostic information that potentially may be used in selection of therapy. With the abovementioned PET tracers available, the need for 123I-MIBG, 18F-DOPA, and 11C-5-HTP may be limited.

Original languageEnglish
Title of host publicationBlistering Diseases: Clinical Features, Pathogenesis, Treatment
Number of pages9
PublisherSpringer Berlin Heidelberg
Publication date01.01.2015
ISBN (Print)9783662456972
ISBN (Electronic)9783662456989
Publication statusPublished - 01.01.2015

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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