Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Marija Dulovic-Mahlow; Agnieszka Lukomska; Sokhna Haissatou Diaw; Alexander Balck; Max Borsche; Karen Grütz; Insa Lenz; Franziska Rudolph; Katja Lohmann; Christine Klein; Philip Seibler

doi:10.1016/j.scr.2019.101629

Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Marija Dulovic-Mahlow, Agnieszka Lukomska, Sokhna Haissatou Diaw, Alexander Balck, Max Borsche, Karen Grütz, Insa Lenz, Franziska Rudolph, Katja Lohmann, Christine Klein, Philip Seibler

1 Citation (Scopus)

Abstract

Despite a genetic component in the development of Parkinson's disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus and the iPSC lines were comprehensively characterized. These lines provide a valuable resource for studying molecular differences between the affected and unaffected monozygotic twin and their response to genetic and non-genetic factors that might be involved in the development of PD.

Original language	English
Article number	101629
Journal	Stem Cell Research
Volume	41
ISSN	1873-5061
DOIs	https://doi.org/10.1016/j.scr.2019.101629
Publication status	Published - 12.2019

Funding

This work was funded by the German Research Foundation ( FOR2488 ). A.L. and S.H.D. received scholarships from the ERASMUS programme. We thank the Oxford Genomic Centre at the Wellcome Centre for Human Genetics for the generation of Genotyping data.

Research Areas and Centers

Research Area: Medical Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.scr.2019.101629

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title = "Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease",

abstract = "Despite a genetic component in the development of Parkinson's disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus and the iPSC lines were comprehensively characterized. These lines provide a valuable resource for studying molecular differences between the affected and unaffected monozygotic twin and their response to genetic and non-genetic factors that might be involved in the development of PD.",

author = "Marija Dulovic-Mahlow and Agnieszka Lukomska and Diaw, \{Sokhna Haissatou\} and Alexander Balck and Max Borsche and Karen Gr{\"u}tz and Insa Lenz and Franziska Rudolph and Katja Lohmann and Christine Klein and Philip Seibler",

year = "2019",

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doi = "10.1016/j.scr.2019.101629",

language = "English",

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journal = "Stem Cell Research",

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TY - JOUR

T1 - Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

AU - Dulovic-Mahlow, Marija

AU - Lukomska, Agnieszka

AU - Diaw, Sokhna Haissatou

AU - Balck, Alexander

AU - Borsche, Max

AU - Grütz, Karen

AU - Lenz, Insa

AU - Rudolph, Franziska

AU - Lohmann, Katja

AU - Klein, Christine

AU - Seibler, Philip

PY - 2019/12

Y1 - 2019/12

N2 - Despite a genetic component in the development of Parkinson's disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus and the iPSC lines were comprehensively characterized. These lines provide a valuable resource for studying molecular differences between the affected and unaffected monozygotic twin and their response to genetic and non-genetic factors that might be involved in the development of PD.

AB - Despite a genetic component in the development of Parkinson's disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus and the iPSC lines were comprehensively characterized. These lines provide a valuable resource for studying molecular differences between the affected and unaffected monozygotic twin and their response to genetic and non-genetic factors that might be involved in the development of PD.

UR - https://www.scopus.com/pages/publications/85074429783

U2 - 10.1016/j.scr.2019.101629

DO - 10.1016/j.scr.2019.101629

M3 - Journal articles

C2 - 31706098

AN - SCOPUS:85074429783

SN - 1873-5061

VL - 41

JO - Stem Cell Research

JF - Stem Cell Research

M1 - 101629

ER -

Generation and characterization of human-derived iPSC lines from three pairs of monozygotic twins discordant for Parkinson's disease

Abstract

Funding

Research Areas and Centers

UN SDGs

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