TY - JOUR
T1 - General psychopathology links burden of recent life events and psychotic symptoms in a network approach
AU - Betz, Linda T.
AU - the PRONIA consortium
AU - Penzel, Nora
AU - Kambeitz-Ilankovic, Lana
AU - Rosen, Marlene
AU - Chisholm, Katharine
AU - Stainton, Alexandra
AU - Haidl, Theresa K.
AU - Wenzel, Julian
AU - Bertolino, Alessandro
AU - Borgwardt, Stefan
AU - Brambilla, Paolo
AU - Lencer, Rebekka
AU - Meisenzahl, Eva
AU - Ruhrmann, Stephan
AU - Salokangas, Raimo K.R.
AU - Schultze-Lutter, Frauke
AU - Wood, Stephen J.
AU - Upthegrove, Rachel
AU - Koutsouleris, Nikolaos
AU - Kambeitz, Joseph
N1 - Funding Information:
PRONIA is a Collaboration Project funded by the European Union under the 7th Framework Programme (grant agreement n° 602152). J.K. has received funding from the German Research Foundation (DFG; grant agreement n° KA 4413/1-1).
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.
AB - Recent life events have been implicated in the onset and progression of psychosis. However, psychological processes that account for the association are yet to be fully understood. Using a network approach, we aimed to identify pathways linking recent life events and symptoms observed in psychosis. Based on previous literature, we hypothesized that general symptoms would mediate between recent life events and psychotic symptoms. We analyzed baseline data of patients at clinical high risk for psychosis and with recent-onset psychosis (n = 547) from the Personalised Prognostic Tools for Early Psychosis Management (PRONIA) study. In a network analysis, we modeled links between the burden of recent life events and all individual symptoms of the Positive and Negative Syndrome Scale before and after controlling for childhood trauma. To investigate the longitudinal associations between burden of recent life events and symptoms, we analyzed multiwave panel data from seven timepoints up to month 18. Corroborating our hypothesis, burden of recent life events was connected to positive and negative symptoms through general psychopathology, specifically depression, guilt feelings, anxiety and tension, even after controlling for childhood trauma. Longitudinal modeling indicated that on average, burden of recent life events preceded general psychopathology in the individual. In line with the theory of an affective pathway to psychosis, recent life events may lead to psychotic symptoms via heightened emotional distress. Life events may be one driving force of unspecific, general psychopathology described as characteristic of early phases of the psychosis spectrum, offering promising avenues for interventions.
UR - http://www.scopus.com/inward/record.url?scp=85097630600&partnerID=8YFLogxK
U2 - 10.1038/s41537-020-00129-w
DO - 10.1038/s41537-020-00129-w
M3 - Journal articles
AN - SCOPUS:85097630600
SN - 2334-265X
VL - 6
JO - npj Schizophrenia
JF - npj Schizophrenia
IS - 1
M1 - 40
ER -