TY - JOUR
T1 - General practice recommendations for the topical treatment of psoriasis: a modified-Delphi approach
AU - Thaçi, Diamant
AU - de la Cueva, Pablo
AU - Pink, Andrew E.
AU - Jalili, Ahmad
AU - Segaert, Siegfried
AU - Hjuler, Kasper F.
AU - Calzavara-Pinton, Piergiacomo
N1 - Funding Information:
This work was sponsored by LEO Pharma, which provided funding for experts to attend a meeting to discuss practical recommendations on the use of topical treatments for psoriasis, and for medical writing assistance. LEO Pharma was not involved in the generation of recommendations.
Funding Information:
The authors would like to extend their gratitude to Professor Peter Berg for his participation in the working group as he played a key role in the identification of key questions, literature research, and the development and review of summary statements and clinical recommendations. The following physicians were also involved in the programme, comprising the wider expert group: Kashif Bhatti, UK; Bernadette Blouard, Belgium; Noelle Colin-Chamley, France; Wim de Kort, the Netherlands; Peter Foley, Australia; Stamatis Gregoriou, Greece; Kurt Gebauer, Australia; Bruno Halioua, France; Jose Luis López Estebaranz, Spain; Anna Szponar-Bojda, Poland; Tiago Torres, Portugal; Dagmar Wilsmann-Theis, Germany. The authors thank these experts for their input into the statements and recommendations, and in helping them to evolve the article into the final output presented here. Medical writing support (including publication planning and scientific editorial services) was provided by Leading Edge Medical Communications, Ltd., Loudwater, UK, funded by LEO Pharma A/S.
Publisher Copyright:
© 2020. The Authors. All Rights Reserved.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/12
Y1 - 2020/12
N2 - Background: Although GPs are usually the first port of call for patients with psoriasis, there is a lack of consistent and up-to-date clinical recommendations for interventions for patients with mild-to-moderate disease. Aim: To provide practical recommendations for GPs to optimise psoriasis treatment with topical therapies in four key areas: patient identification; treatment decision making with topical theory; topical treatment outcomes; and optimising patient adherence. Design & setting: A consensus-seeking programme (modified-Delphi approach) was undertaken to assess the literature and develop recommendations for GPs, based on evidence and expert opinion. Method: Three dermatologists compiled 47 questions that were subsequently ranked and refined according to clinical relevance or importance using an online survey. Thereafter, 19 dermatologists from different European countries developed statements and clinical recommendations for the top seven ranked topical treatment and GP-relevant questions based on literature research and clinical experience. The final recommendations were based on 100% agreement among a final panel of seven experts. Results: The clinical effectiveness, fast onset of action, tolerability, cosmetic acceptability, and practicability of topical therapy, in addition to good physician—patient communication, are important for optimising patient adherence and maximising efficacy. Topical treatments combining corticosteroids and vitamin D analogues (administered as fixed combination) are well-established first-line treatments in mild-to-moderate psoriasis. Conclusion: Simple but detailed practical guidance is provided, which is formed from evidence and expert clinical recommendations, to assist GPs with the optimal use of topical agents based on efficacy, tolerability, disease severity, site of psoriasis, patient lifestyle and preferences, and intended duration of treatment.
AB - Background: Although GPs are usually the first port of call for patients with psoriasis, there is a lack of consistent and up-to-date clinical recommendations for interventions for patients with mild-to-moderate disease. Aim: To provide practical recommendations for GPs to optimise psoriasis treatment with topical therapies in four key areas: patient identification; treatment decision making with topical theory; topical treatment outcomes; and optimising patient adherence. Design & setting: A consensus-seeking programme (modified-Delphi approach) was undertaken to assess the literature and develop recommendations for GPs, based on evidence and expert opinion. Method: Three dermatologists compiled 47 questions that were subsequently ranked and refined according to clinical relevance or importance using an online survey. Thereafter, 19 dermatologists from different European countries developed statements and clinical recommendations for the top seven ranked topical treatment and GP-relevant questions based on literature research and clinical experience. The final recommendations were based on 100% agreement among a final panel of seven experts. Results: The clinical effectiveness, fast onset of action, tolerability, cosmetic acceptability, and practicability of topical therapy, in addition to good physician—patient communication, are important for optimising patient adherence and maximising efficacy. Topical treatments combining corticosteroids and vitamin D analogues (administered as fixed combination) are well-established first-line treatments in mild-to-moderate psoriasis. Conclusion: Simple but detailed practical guidance is provided, which is formed from evidence and expert clinical recommendations, to assist GPs with the optimal use of topical agents based on efficacy, tolerability, disease severity, site of psoriasis, patient lifestyle and preferences, and intended duration of treatment.
UR - http://www.scopus.com/inward/record.url?scp=85100067967&partnerID=8YFLogxK
U2 - 10.3399/bjgpopen20X101108
DO - 10.3399/bjgpopen20X101108
M3 - Journal articles
AN - SCOPUS:85100067967
SN - 1849-5435
VL - 4
SP - 1
EP - 11
JO - BJGP Open
JF - BJGP Open
IS - 5
ER -