Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack; Matthias Naegele; Cathleen Haueis; Sven Schippling; Klaus Peter Wandinger; Roland Martin; Mireia Sospedra

doi:10.1016/j.jneuroim.2013.05.004

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Kati Tillack, Matthias Naegele, Cathleen Haueis, Sven Schippling, Klaus Peter Wandinger, Roland Martin, Mireia Sospedra^*

^*Corresponding author for this work

Institute of Clinical Chemistry

81 Citations (Scopus)

Abstract

Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

Original language	English
Journal	Journal of Neuroimmunology
Volume	261
Issue number	1-2
Pages (from-to)	108-119
Number of pages	12
ISSN	0165-5728
DOIs	https://doi.org/10.1016/j.jneuroim.2013.05.004
Publication status	Published - 15.08.2013

Funding

We thank all the patients and healthy donors for their blood donations and the staff of the INiMS outpatient clinic and the staff of the Department for Transfusion Medicine, University Medical Centre Hamburg-Eppendorf for providing the samples. The INiMS was supported by the Gemeinnützige Hertie Stiftung, and this project was supported by the DFG grant SO 1029/1-1 . Appendix A

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.jneuroim.2013.05.004

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title = "Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients",

abstract = "Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.",

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AU - Tillack, Kati

AU - Naegele, Matthias

AU - Haueis, Cathleen

AU - Schippling, Sven

AU - Wandinger, Klaus Peter

AU - Martin, Roland

AU - Sospedra, Mireia

PY - 2013/8/15

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N2 - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

AB - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.

UR - https://www.scopus.com/pages/publications/84880834836

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JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients

Abstract

Funding

UN SDGs

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