TY - JOUR
T1 - Gender differences in circulating levels of neutrophil extracellular traps in serum of multiple sclerosis patients
AU - Tillack, Kati
AU - Naegele, Matthias
AU - Haueis, Cathleen
AU - Schippling, Sven
AU - Wandinger, Klaus Peter
AU - Martin, Roland
AU - Sospedra, Mireia
PY - 2013/8/15
Y1 - 2013/8/15
N2 - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.
AB - Neutrophil extracellular traps (NETs) trap and kill pathogens very efficiently but also activate dendritic cells and prime T cells. Previously, we demonstrated that neutrophils are primed and circulating NETs are elevated in relapsing remitting multiple sclerosis (RRMS), a T cell-mediated autoimmune disease. Here, we demonstrate gender specific differences in circulating NETs but not in neutrophil priming in RRMS patients. Although the results from our systematic and in depth characterization of these patients argue against a major role of circulating NETs in this disease, they suggest that NETs may underlie gender-specific differences in MS pathogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84880834836&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2013.05.004
DO - 10.1016/j.jneuroim.2013.05.004
M3 - Journal articles
C2 - 23735283
AN - SCOPUS:84880834836
VL - 261
SP - 108
EP - 119
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1-2
ER -