Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model

Martin Grossherr; A. Hager; T. Gerriets; E. G. Kraatz; M. Misfeld; K. F. Klotz

Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model

Martin Grossherr^*, A. Hager, T. Gerriets, E. G. Kraatz, M. Misfeld, K. F. Klotz

^*Corresponding author for this work

Abstract

The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg^-1h^-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparably in both groups. Plasma viscosity was higher after HES than after GEL. Systolic central retinal blood flow and resistance index increased and were higher after HES than after GEL. Despite a greater plasma viscosity HES increases retinal microcirculation during hypervolemic hemodilution.

Original language	English
Journal	Applied Cardiopulmonary Pathophysiology
Volume	12
Issue number	1
Pages (from-to)	40-46
Number of pages	7
ISSN	0920-5268
Publication status	Published - 2008

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Grossherr, M., Hager, A., Gerriets, T., Kraatz, E. G., Misfeld, M., & Klotz, K. F. (2008). Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model. Applied Cardiopulmonary Pathophysiology, 12(1), 40-46. http://www.applied-cardiopulmonary-pathophysiology.com/fileadmin/downloads/acp-2008-1/07_grossherr.pdf

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title = "Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model",

abstract = "The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg-1h-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparably in both groups. Plasma viscosity was higher after HES than after GEL. Systolic central retinal blood flow and resistance index increased and were higher after HES than after GEL. Despite a greater plasma viscosity HES increases retinal microcirculation during hypervolemic hemodilution.",

author = "Martin Grossherr and A. Hager and T. Gerriets and Kraatz, {E. G.} and M. Misfeld and Klotz, {K. F.}",

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journal = "Applied Cardiopulmonary Pathophysiology",

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Grossherr, M, Hager, A, Gerriets, T, Kraatz, EG, Misfeld, M & Klotz, KF 2008, 'Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model', Applied Cardiopulmonary Pathophysiology, vol. 12, no. 1, pp. 40-46. <http://www.applied-cardiopulmonary-pathophysiology.com/fileadmin/downloads/acp-2008-1/07_grossherr.pdf>

TY - JOUR

T1 - Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model

AU - Grossherr, Martin

AU - Hager, A.

AU - Gerriets, T.

AU - Kraatz, E. G.

AU - Misfeld, M.

AU - Klotz, K. F.

PY - 2008

Y1 - 2008

N2 - The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg-1h-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparably in both groups. Plasma viscosity was higher after HES than after GEL. Systolic central retinal blood flow and resistance index increased and were higher after HES than after GEL. Despite a greater plasma viscosity HES increases retinal microcirculation during hypervolemic hemodilution.

AB - The present study was designed to determine the effects of hemodilution with gelatine (GEL) and hydroxyethyl starch (HES) on hematocrit, blood viscosity, systemic hemodynamics, and central retinal arterial blood flow in anaesthetized pigs. 20 pigs were studied. Hypervolemic hemodilution was induced by 30 ml kg-1h-1 GEL (n=10) or HES (n=10) infused over 30 min. The hematocrit decreased comparably in both groups. Plasma viscosity was higher after HES than after GEL. Systolic central retinal blood flow and resistance index increased and were higher after HES than after GEL. Despite a greater plasma viscosity HES increases retinal microcirculation during hypervolemic hemodilution.

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M3 - Journal articles

AN - SCOPUS:65949084016

SN - 0920-5268

VL - 12

SP - 40

EP - 46

JO - Applied Cardiopulmonary Pathophysiology

JF - Applied Cardiopulmonary Pathophysiology

IS - 1

ER -

Gelatine and hydroxyl ethyl starch hypervolemic hemodilution - Effect on hemorheology and retinal circulation in a pig model

Abstract

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