Galectin-3 in cord blood of term and preterm infants

M. Demmert, K. Faust, M. K. Bohlmann, B. Tröger, W. Göpel, E. Herting, C. Härtel*

*Corresponding author for this work
9 Citations (Scopus)


In recent years galectin-3 has gained attention as a signalling molecule, mainly in inflammatory diseases. Data on galectin-3 expression in neonates, however, are limited, and expression of this lectin in cord blood has not yet been reported. The aim of this study was to determine galectin-3 levels in cord blood of term and preterm neonates as well as galectin-3 levels in cord blood of term neonates after stimulation with the prevalent pathogen Streptococcusagalactiae. Cord blood samples were incubated for 24h and galectin-3 levels were assessed by enzyme-linked immunosorbent assay. There is a positive correlation between gestational age and galectin-3 levels in cord blood. Expression of galectin-3 is significantly higher in cord blood of small-for-gestational-age infants compared to appropriate-for-gestational-age infants. Stimulation with an invasive but not with a colonizing strain of S.agalactiae induced expression of galectin-3. Galectin-3 is expressed constitutively in cord blood of neonates and seems to play a role in the innate immunity of this population.

Original languageEnglish
JournalClinical and Experimental Immunology
Issue number2
Pages (from-to)246-251
Number of pages6
Publication statusPublished - 01.02.2012


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