TY - JOUR
T1 - FUT 2 polymorphism and outcome in very-low-birth-weight infants
AU - Demmert, Martin
AU - Schaper, Anne
AU - Pagel, Julia
AU - Gebauer, Corinna
AU - Emeis, Michael
AU - Heitmann, Friedhelm
AU - Kribs, Angela
AU - Siegel, Jens
AU - Müller, Dirk
AU - Keller-Wackerbauer, Annette
AU - Gerleve, Hubert
AU - Wieg, Christian
AU - Herting, Egbert
AU - Göpel, Wolfgang
AU - Härtel, Christoph
N1 - Publisher Copyright:
© 2015 International Pediatric Research Foundation, Inc.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/4/19
Y1 - 2015/4/19
N2 - Background:To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.Methods:We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.Results:Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs. GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.Conclusion:This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.
AB - Background:To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants.Methods:We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death.Results:Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs. GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model.Conclusion:This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.
UR - http://www.scopus.com/inward/record.url?scp=84924967767&partnerID=8YFLogxK
U2 - 10.1038/pr.2015.1
DO - 10.1038/pr.2015.1
M3 - Journal articles
C2 - 25642664
AN - SCOPUS:84924967767
SN - 0031-3998
VL - 77
SP - 586
EP - 590
JO - Pediatric Research
JF - Pediatric Research
IS - 4
ER -
