TY - JOUR
T1 - Functional polymorphism in the Neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women
AU - Mutschler, Jochen
AU - Abbruzzese, Elvira
AU - Wiedemann, Klaus
AU - Von Der Goltz, Christoph
AU - Dinter, Christina
AU - Mobascher, Arian
AU - Thiele, Holger
AU - Diaz-Lacava, Amalia
AU - Dahmen, Norbert
AU - Gallinat, Jürgen
AU - Majic, Tomislav
AU - Petrovsky, Nadine
AU - Thuerauf, Norbert
AU - Kornhuber, Johannes
AU - Gründer, Gerhard
AU - Rademacher, Lena
AU - Brinkmeyer, Juergen
AU - Wienker, Thomas
AU - Wagner, Michael
AU - Winterer, Georg
AU - Kiefer, Falk
N1 - Publisher Copyright:
© 2013 S. Karger AG, Basel.
PY - 2013
Y1 - 2013
N2 - Objective: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution. Method: We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR). Results: We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men. Conclusion: Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.
AB - Objective: The neuropeptide-Y (NP-Y) gene is a strong candidate gene in the pathophysiology of obesity-linked behavior, and several single-nucleotide polymorphisms of NP-Y have already been linked to body weight and appetite. However, the results from current studies remain inconclusive. The aim of the present study was to test whether a certain functional genetic variant (SNP rs16147) in the NP-Y promoter gene is associated with serum leptin levels and body fat distribution. Method: We genotyped and measured the serum leptin levels of the NP-Y rs16147 polymorphism in 1,097 Caucasian subjects in the context of a population-based, case-control multicenter study. We measured weight, height and waist circumference, from which we then calculated BMI and waist-to-hip ratio (WHR). Results: We found the CT-genotype of the SNP rs16147 to be significantly associated with lower WHRs and higher serum leptin levels in women, compared to homozygote gene carriers. No association between rs16147, WHR and serum leptin levels was found in men. Conclusion: Our results provide evidence that the functionally relevant SNP in the NP-Y promoter gene affects body fat distribution and serum leptin levels in women, pointing towards possible behavioral effects of NPY in obesity.
UR - http://www.scopus.com/inward/record.url?scp=84877649463&partnerID=8YFLogxK
U2 - 10.1159/000346799
DO - 10.1159/000346799
M3 - Journal articles
AN - SCOPUS:84877649463
SN - 0250-6807
VL - 62
SP - 271
EP - 276
JO - Annals of Nutrition and Metabolism
JF - Annals of Nutrition and Metabolism
IS - 4
ER -
