Functional brain network dysfunctions in subjects at high-risk for psychosis: A meta-analysis of resting-state functional connectivity

Lorenzo Del Fabro, André Schmidt, Lydia Fortea, Giuseppe Delvecchio, Armando D'Agostino, Joaquim Radua, Stefan Borgwardt, Paolo Brambilla*

*Corresponding author for this work
4 Citations (Scopus)

Abstract

Although emerging evidence suggests that altered functional connectivity (FC) of large-scale neural networks is associated with disturbances in individuals at high-risk for psychosis, the findings are still far to be conclusive. We conducted a meta-analysis of seed-based resting-state functional magnetic resonance imaging studies that compared individuals at clinical high-risk for psychosis (CHR), first-degree relatives of patients with schizophrenia, or subjects who reported psychotic-like experiences with healthy controls. Twenty-nine studies met the inclusion criteria. The MetaNSUE method was used to analyze connectivity comparisons and symptom correlations. Our results showed a significant hypo-connectivity within the salience network (p = 0.012, uncorrected) in the sample of CHR individuals (n = 810). Additionally, we found a positive correlation between negative symptom severity and FC between the default mode network and both the salience network (p < 0.001, r = 0.298) and the central executive network (p = 0.003, r = 0.23) in the CHR group. This meta-analysis lends support for the hypothesis that large-scale network dysfunctions represent a core neural deficit underlying psychosis development.

Original languageEnglish
JournalNeuroscience and Biobehavioral Reviews
Volume128
Pages (from-to)90-101
Number of pages12
ISSN0149-7634
DOIs
Publication statusPublished - 09.2021

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 206-04 Cognitive, Systemic and Behavioural Neurobiology
  • 206-10 Clinical Psychiatry, Psychotherapy amd Paediatric and Juvenile Psychiatrie
  • 206-09 Biological Psychiatry

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