TY - JOUR
T1 - Functional and genetic deconstruction of the cellular origin in liver cancer
AU - Marquardt, Jens U.
AU - Andersen, Jesper B.
AU - Thorgeirsson, Snorri S.
N1 - Publisher Copyright:
© 2015 Macmillan Publishers Limited. All rights reserved.
PY - 2015/10/23
Y1 - 2015/10/23
N2 - During the past decade, research on primary liver cancers has particularly highlighted the uncommon plasticity of differentiated parenchymal liver cells (that is, hepatocytes and cholangiocytes (also known as biliary epithelial cells)), the role of liver progenitor cells in malignant transformation, the importance of the tumour microenvironment and the molecular complexity of liver tumours. Whereas other reviews have focused on the landscape of genetic alterations that promote development and progression of primary liver cancers and the role of the tumour microenvironment, the crucial importance of the cellular origin of liver cancer has been much less explored. Therefore, in this Review, we emphasize the importance and complexity of the cellular origin in tumour initiation and progression, and attempt to integrate this aspect with recent discoveries in tumour genomics and the contribution of the disrupted hepatic microenvironment to liver carcinogenesis.
AB - During the past decade, research on primary liver cancers has particularly highlighted the uncommon plasticity of differentiated parenchymal liver cells (that is, hepatocytes and cholangiocytes (also known as biliary epithelial cells)), the role of liver progenitor cells in malignant transformation, the importance of the tumour microenvironment and the molecular complexity of liver tumours. Whereas other reviews have focused on the landscape of genetic alterations that promote development and progression of primary liver cancers and the role of the tumour microenvironment, the crucial importance of the cellular origin of liver cancer has been much less explored. Therefore, in this Review, we emphasize the importance and complexity of the cellular origin in tumour initiation and progression, and attempt to integrate this aspect with recent discoveries in tumour genomics and the contribution of the disrupted hepatic microenvironment to liver carcinogenesis.
UR - http://www.scopus.com/inward/record.url?scp=84944906098&partnerID=8YFLogxK
U2 - 10.1038/nrc4017
DO - 10.1038/nrc4017
M3 - Scientific review articles
C2 - 26493646
AN - SCOPUS:84944906098
SN - 1474-175X
VL - 15
SP - 653
EP - 667
JO - Nature Reviews Cancer
JF - Nature Reviews Cancer
IS - 11
ER -
