Free-form registration using mutual information and curvature regularization

E. D'Agostino*, J. Modersitzki, F. Maes, D. Vandermeulen, B. Fischer, P. Suetens

*Corresponding author for this work
7 Citations (Scopus)


In this paper we present a novel 3-D free-form non-rigid registration algorithm which combines the mutual information similarity measure with a particular curvature based regularizer, which has been demonstrated to produce very satisfactory results in conjunction with the sum of squared differences distance measure. The method is evaluated for inter-subject MR brain image registration using simulated deformations and compared with a scheme that applies the same similarity measure but with a viscous fluid regularizer.

Original languageEnglish
JournalLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Pages (from-to)11-20
Number of pages10
Publication statusPublished - 01.12.2003


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