Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues

Sebastian Marwitz, Lena Heinbockel, Swetlana Scheufele, Christian Kugler, Martin Reck, Klaus F. Rabe, Sven Perner, Torsten Goldmann*, Ole Ammerpohl

*Corresponding author for this work
3 Citations (Scopus)

Abstract

Aging affects the core processes of almost every organism, and the functional decline at the cellular and tissue levels influences disease development. Recently, it was shown that the methylation of certain CpG dinucleotides correlates with chronological age and that this epigenetic clock can be applied to study aging-related effects. We investigated these molecular age loci in non-small cell lung cancer (NSCLC) tissues from patients with adenocarcinomas (AC) and squamous cell carcinomas (SQC) as well as in matched tumor-free lung tissue. In both NSCLC subtypes, the calculated epigenetic age did not correlate with the chronological age. In particular, SQC exhibited rejuvenation compared to the corresponding normal lung tissue as well as with the chronological age of the donor. Moreover, the younger epigenetic pattern was associated with a trend toward stem cell-like gene expression patterns. These findings show deep phenotypic differences between the tumor entities AC and SQC, which might be useful for novel therapeutic and diagnostic approaches.

Original languageEnglish
JournalInternational Journal of Cancer
Volume143
Issue number12
Pages (from-to)3061-3070
Number of pages10
ISSN0020-7136
DOIs
Publication statusPublished - 15.12.2018

Fingerprint

Dive into the research topics of 'Fountain of youth for squamous cell carcinomas? On the epigenetic age of non-small cell lung cancer and corresponding tumor-free lung tissues'. Together they form a unique fingerprint.

Cite this