Abstract
The circadian clock is an evolutionarily highly conserved endogenous : timing program that structures physiology and behavior according to the time of day. Disruption of circadian rhythms is associated with many common pathologies. The emerging field of circadian medicine aims to exploit the mechanisms of circadian physiology and clock–disease interaction for clinical diagnosis, treatment, and prevention. In this Essay, we outline the principle approaches of circadian medicine, highlight the development of the field in selected areas, and point out open questions and challenges. Circadian medicine has unambiguous health benefits over standard care but is rarely utilized. It is time for clock biology to become an integrated part of translational research.
| Original language | English |
|---|---|
| Article number | e3001567 |
| Journal | PLOS Biology |
| Volume | 20 |
| Issue number | 3 |
| ISSN | 1544-9173 |
| DOIs | |
| Publication status | Published - 03.2022 |
Funding
issuedpatents(PCT/EP2018/066771)andis preparingpatentsrelatedtobiomarkersfor detectingtheclock.Thisintellectualpropertyhas beenlicensedbyBodyClockGmbH,inwhichAKis ashareholder.AKreceiveseditor’shonorariafrom SpringerVerlagandGeorgThiemeVerlag.AKisa paidconsultanttoCircadianTherapeutics,and StanfordUniversity.AKismemberoftheEditorial BoardofPLoSBiology.Inaddition,heandhis researchprogramhavereceivedfinancial,material andtravelsupportfromarangeoffederal, industrial,legalandphilanthropicorganizationsin thepastandpresent.CSreportsgrantsfrom DeutscheForschungsgemeinschaft/German ResearchSociety,grantsfromDeutschesZentrum fu ¨r Luft-und Raumfahrte. V. (DLR)/German AerospaceCenter,grantsfromEinsteinStiftung Berlin/EinsteinFoundationBerlin,grantsfrom GemeinsamerBundesausschuss/FederalJoint Committee(G-BA),grantsfromInneruniversita ¨re Forschungsfo ¨rderung / InnerUniversity Grants, grantsfromProjekttra¨gerimDLR/Project ManagementAgency,grantsfromStifterverband/ Non-ProfitSocietyPromotingScienceand Education,grantsfromEuropeanSocietyof AnaesthesiologyandIntensiveCare,grantsfrom BaxterDeutschlandGmbH,grantsfrom CytosorbentsEuropeGmbH,grantsfromEdwards LifesciencesGermanyGmbH,grantsfrom FreseniusMedicalCare,grantsfromGru ¨nenthal GmbH,grantsfromMasimoEuropeLtd.,grants fromPfizerPharmaPFEGmbH,personalfeesfrom GeorgThiemeVerlag,grantsfromDr.F.Ko ¨hler ChemieGmbH,grantsfromSinteticaGmbH, grants from Stifterverband fu ¨r die deutsche Wissenschafte.V./PhilipsgrantsfromStiftung Charite ´,grantsfromAGUETTANTDeutschland GmbH,grantsfromAbbVieDeutschlandGmbH& Co.KG,grantsfromAmomedPharmaGmbH, grantsfromInTouchHealth,grantsfromCopra SystemGmbH,grantsfromCorrevioGmbH, grantsfromMax-Planck-Gesellschaftzur Fo ¨rderungderWissenschaftene.V.,grantsfrom Deutsche Gesellschaft fu ¨r Ana ¨sthesiologie& Intensivmedizin(DGAI,grantsfromStifterverband fu ¨r die deutscheWissenschaft Þ.V. / Metronic, grantsfromPhilipsElectronicsNederlandBV, grantsfromBMG,grantsfromBMBF,grantsfrom BMBF,grantsfromDra ¨gerwerkAG&Co.KGaA, outsidethesubmittedwork;Inaddition,CShasa patent102014215211.9licensed,apatent10 2018114364.8licensed,apatent102018110 275.5licensed,apatent502015010534.8 licensed,apatent502015010347.7licensed,and apatent102014215212.7licensed.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
DFG Research Classification Scheme
- 2.22-17 Endocrinology, Diabetology, Metabolism
- 2.23-08 Human Cognitive and Systems Neuroscience
