Abstract
Background/Aim: FOLFIRINOX [fluorouracil (5- FU), irinotecan, oxaliplatin] and gemcitabine plus nabpaclitaxel are standard treatments for patients with pancreatic ductal adenocarcinoma (PDAC). Despite efficacy rates of less than 32%, evidence is lacking to guide the use of one drug over the other. Herein, we compared the sensitivity of patient-derived PDAC cell lines to each of these regimens. Materials and Methods: Changes in the growth of 19 low-passage patientderived PDAC cell lines were evaluated in response to treatment with FOLFIRINOX and gemcitabine plus paclitaxel (Gem-Pac). Results: Six cell lines exhibited optimal sensitivity (high EMaxand low GI50) to FOLFIRINOX and three cell lines exhibited optimal sensitivity to Gem-Pac. Several cell lines that were optimally sensitive to one drug regimen exhibited very poor response to the other. Conclusion: Further characterization of cancer cells exhibiting preferential sensitivity to each of these regimens may allow the identification of biomarkers to guide the selection of appropriate chemotherapy for a given patient.
Original language | English |
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Journal | Anticancer Research |
Volume | 40 |
Issue number | 7 |
Pages (from-to) | 3659-3667 |
Number of pages | 9 |
ISSN | 0250-7005 |
DOIs | |
Publication status | Published - 07.2020 |
Research Areas and Centers
- Research Area: Luebeck Integrated Oncology Network (LION)