Fluorescence-guided laser lithotripsy: Estimation of the potential effectiveness and safety increase based on first clinical data

B. Lange*, T. Ozimek, J. R. Wießmeyer, M. W. Kramer, A. S. Merseburger, R. Brinkmann

*Corresponding author for this work
1 Citation (Scopus)


In clinically approved laser lithotripsy systems, there is no automatic monitoring of fiber position to date. We investigated whether detecting stone autofluorescence, excited by a green aiming beam, is possible via the fiber during fragmentation by continuously recording the fluorescence signal in 12 ureterosopic lithotripsy procedures. We estimated which threshold the fluorescence signal's amplitude exceeds before laser pulses with visible stone removal by retrospective inspection of the endoscope's video data. For all procedures, blocking the laser when the fluorescence amplitude is below a threshold corresponding to the signal's baseline plus its range (maximum–minimum value) would have been appropriate to suppress ineffective pulses—the energy input could have been reduced by a mean of 14% (1%–29%) without changing the operation time. Ablation of the PTFE coating of the guidewire could have been prevented three times and cutting of a wire of the retrieval basket two times. (Figure presented.).

Original languageEnglish
Article numbere202300044
JournalJournal of Biophotonics
Issue number8
Pages (from-to)e202300044
Publication statusPublished - 08.2023

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)
  • Centers: University Cancer Center Schleswig-Holstein (UCCSH)
  • Academic Focus: Biomedical Engineering

DFG Research Classification Scheme

  • 205-32 Medical Physics, Biomedical Engineering
  • 205-14 Haematology, Oncology

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